Wyman et al., J Leukoc Biol 2002
(Calcium Signaling...) :
IL-18 activation of PMNs was blocked by inhibition of p38 MAP kinase activity ( SB203580 ) or by inhibition of p38 MAP kinase activation by chelation of cytosolic Ca2+
Mavropoulos et al., Blood 2005
:
Mitogen activated protein kinase p38 was activated strongly by IL-18 and weakly by IL-12 in natural killer cells but was not activated by either cytokine in T cells
Elbim et al., Clin Diagn Lab Immunol 2005
:
Flow cytometric analysis of intact PMNs in whole blood showed that IL-18 increased p38MAPK phosphorylation and tyrosine phosphorylation
Tranter et al., Free Radic Biol Med 2008
(Inflammation) :
HO-1 and CO act to suppress IL-18 mediated activation of p38alpha and to restore p38beta activity, which is suppressed by IL-18