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IL1R1 — TRAF6

Pathways - manually collected, often from reviews:

• BioCarta nf-kb signaling pathway: IL-1/IL-1R/MYD88/IRAK/TRAF6 complex (IL1A-IL1R1-MYD88-IRAK1-TRAF6) → IL-1-alpha (IL1A) (modification, collaborate)
• BioCarta nf-kb signaling pathway: IL-1/IL-1R/MYD88/IRAK/TRAF6 complex (IL1A-IL1R1-MYD88-IRAK1-TRAF6) → IL-1R/MYD88/IRAK/TRAF6 complex (IL1R1-MYD88-IRAK1-TRAF6) (modification, collaborate)
  
• BioCarta nf-kb signaling pathway: IL-1-alpha (IL1A) → IL-1R/MYD88/IRAK/TRAF6 complex (IL1R1-MYD88-IRAK1-TRAF6) (modification, collaborate)
  
• BioCarta signal transduction through il1r: IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) → TRAF6 (modification, activates)
• BioCarta nf-kb signaling pathway: IL-1/IL-1R/MYD88/IRAK/TRAF6 complex (IL1A-IL1R1-MYD88-IRAK1-TRAF6) → TAB1/TAK1 complex (MAP3K7IP1-MAP3K7) (modification, activates)
  
• BioCarta nf-kb signaling pathway: IL-1/IL-1R/MYD88/IRAK/TRAF6 complex (IL1A-IL1R1-MYD88-IRAK1-TRAF6) → IKK-alpha/MEKK1/NIK complex (CHUK-MAP3K1-MAP4K4) (modification, activates)
  
• KEGG Osteoclast differentiation: IL1R1 → TRAF2/TRAF6 (protein-protein, activation)
• KEGG MAPK signaling pathway: IL1R1/IL1R2 → TRAF6 (protein-protein, indirect effect)
• NCI Pathway Database IL1-mediated signaling events: TRAF6 (TRAF6) → IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP) (modification, collaborate)
  Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: TRAF6 (TRAF6) → IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) (modification, collaborate)
  Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) → TRAF6 (TRAF6) (modification, collaborate) Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: TRAF6 (TRAF6) → IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6 complex (IRAK1-TRAF6) → IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: TRAF6 (TRAF6) → IL1 beta fragment/IL1R1/IL1RAP/TICAM2/IRAK4 complex (IL1B-IL1R1-IL1RAP-TICAM2-IRAK4) (modification, collaborate)
  Bin et al., J Biol Chem 2003
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/TICAM2/IRAK4 complex (IL1B-IL1R1-IL1RAP-TICAM2-IRAK4) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, activates)
  Bin et al., J Biol Chem 2003
  Evidence: mutant phenotype, physical interaction
• Reactome Reaction: IL1R1 → TRAF6 (reaction) Gottipati et al., Cell Signal 2008, Cao et al., Nature 1996
• Reactome Reaction: IL1R1 → TRAF6 (indirect_complex) Cao et al., Nature 1996
• WikiPathways MAPK Signaling Pathway: IL1R2/IL1R1 → TRAF6 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: IL1R1 — TRAF6 (physical association, affinity chromatography technology) Jiang et al., J Biol Chem 2003
• IRef Biogrid Interaction: IL1R1 — TRAF6 (physical association, affinity chromatography technology) Jiang et al., Mol Cell Biol 2002
• IRef Biogrid Interaction: IL1R1 — TRAF6 (physical association, affinity chromatography technology) Jiang et al., J Biol Chem 2003
• IRef Biogrid Interaction: IL1R1 — TRAF6 (direct interaction, enzymatic study) Elzinga et al., J Biol Chem 2009*
• IRef Biogrid Interaction: IL1R1 — TRAF6 (physical association, affinity chromatography technology) Rafferty et al., Immunol Invest 2010*
• IRef Innatedb Interaction: IL1R1 — TRAF6 (unknown, -) Schmitz et al., Immunity 2005*
• IRef Innatedb Interaction: IL1R1 — TRAF6 (unknown, -) Jiang et al., Mol Cell Biol 2002
• IRef Innatedb Interaction: IL1R1 — TRAF6 (unknown, -) Jiang et al., J Biol Chem 2003
• IRef Innatedb Interaction: IL1R1 — TRAF6 (unknown, -) Li et al., Mol Cell Biol 2006*
• IRef Intact Interaction: Complex of TRAF6-IL1R1-MAP3K14 (association, anti bait coimmunoprecipitation) Li et al., J Biol Chem 2006*
• IRef Intact Interaction: IL1R1 — TRAF6 (physical association, anti bait coimmunoprecipitation) Li et al., J Biol Chem 2006*

Text-mined interactions from Literome

Wang et al., Nat Immunol 2006 : Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling
Chen et al., Cell Signal 2008 : Syntenin negatively regulates TRAF6 mediated IL-1R/TLR4 signaling
Chantzoura et al., Biochem Biophys Res Commun 2010 : Taken together, our findings reveal another signalling molecule affected by S-glutathionylation and uncover a crucial role for GRX-1 in the TRAF6 dependent activation of NF-?B by IL-1R/TLRs