Gene interactions and pathways from curated databases and text-mining

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HSPB1 — IL2

Text-mined interactions from Literome

Binotto et al., Oncology 2003 : In human peripheral blood lymphocytes, IF irreversibly inhibits the proliferative response to interleukin-2 in a dose dependent manner and may also induce the phosphorylation of HSP27 by depleting glutathione
Santell et al., Biochem J 1992 : Down-regulation of protein kinase C-alpha by prolonged treatment with phorbol esters eliminated the ability of phorbol 12-myristate 13-acetate, dioctanoylglycerol, thrombin and histamine to phosphorylate HSP27 above background levels and deceased interleukin-1 stimulated HSP27 phosphorylation by 60 %
Cuenda et al., FEBS Lett 1995 : We now show that one of these compounds ( SB 203580 ) inhibits RK in vitro ( IC50 = 0.6 microM ), suppresses the activation of MAPKAP kinase-2 and prevents the phosphorylation of heat shock protein (HSP) 27 in response to interleukin-1 , cellular stresses and bacterial endotoxin in vivo