Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Gosset et al., Eur Respir J 1999 : Since exogenous as well as endogenous thiols could be potent inhibitors of the production of cytokines, the effects of N-acetylcysteine (NAC) , glutathione ( GSH ) and modulated GSH synthesis on the production of tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-8 by human alveolar macrophages ( AMs ) was evaluated, as well as the potential role of intracellular GSH depletion on the effect of exogenous thiols
Abdel Baki et al., PloS one 2010 (Brain Injuries) : When dosed 3 hours before injury, MINO plus NAC as single drugs had no effect on interleukin-1 formation ; together they synergistically lowered interleukin-1 levels
Ehsani et al., Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 2012 : To evaluate the role of prophylactic ibuprofen and N-acetylcysteine (NAC) on the levels of tumor necrosis factor alpha ( TNF- a ), interleukin- 6(IL-6) and IL-17 and post-treatment pain level in chronic periapical lesions