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IL26 — STAT1
Text-mined interactions from Literome
Subramaniam et al., Biochem Biophys Res Commun 1999
:
Immunoprecipitation with specific antibodies followed by Western blot analysis with antiphosphotyrosine antibody has shown that in U937 cells,
interleukin-17 induces time dependent stimulation of tyrosine phosphorylation of JAK 1, 2 and 3, Tyk 2 and
STAT 1 , 2, 3 and 4 within 0.5 to 30 min. Interleukin-17 mediated tyrosine phosphorylation of these proteins strongly suggests that the JAK/STAT signaling pathway may play a major role in transducing signals from interleukin-17 receptors to the nucleus
Lee et al., J Exp Med 1999
:
Interestingly,
interleukin (IL)-7 selectively
activated STAT1 and induced MHC class I in mature T but not B cells
Braum et al., Antiinflamm Antiallergy Agents Med Chem 2012
(Autoimmune Diseases...) :
IL-26 stimulation
induces STAT1 and STAT3 phosphorylation, CD54 surface expression, and cytokine secretion as shown for IL-8 and IL-10
You et al., PloS one 2013
:
IL-26 activated
STAT1 and STAT3 signaling ; however, the upregulation of the expression of Bcl-2, Bcl-xl and c-myc indicated that the effect of IL-26 is mediated by STAT3 activation ... Knockdown of STAT1 and STAT3 expression suggested that the proliferative and anti-apoptotic effects of
IL-26 are
mediated by the modulation of
STAT1/STAT3 activation