Gene interactions and pathways from curated databases and text-mining

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IL2RA — TNF

Text-mined interactions from Literome

Kim et al., Anticancer Res 2002 (Colonic Neoplasms) : In contrast, during the 18- to 36-hours interval, SL-TNF-alpha induced significantly higher ( p < 0.05 ) leukoctyte, T cell, and NK cell numbers, basal leukocyte proliferation, and CD25+ activation marker expression ; the modulation occurred primarily in the spleen
Tchórzewski et al., Med Sci Monit 2005 (Autoimmune Diseases...) : We analyzed reactive oxygen intermediate ( ROI ) production by peripheral blood granulocytes, the production of IL-2, IL-5, IL-10, IL-12, and TNF-alpha cytokines by lymphocytes, and the activation of CD25 , CD26, CD69, CD71, and HLA DR antigen expression
Barten et al., Transplant Proc 2005 (Gingival Diseases...) : Compared to CsA therapy, increased TRL concentrations did not further inhibit PCNA expression, inhibited CD25 expression less on days 1 and 2 and equally high on day 3, but inhibited expression of IL-2 and TNF-alpha significantly higher on days 2 and 3 ( P < .05 )
Schrepfer et al., Transplant Proc 2006 : TNF-alpha stimulation and TCR/CD28 co-stimulation significantly increased EC ICAM-1/VCAM-1-expression and LC CD25 surface expression, respectively
van de Linde et al., Hum Immunol 2006 (Diabetes Mellitus, Type 1) : Modulation of cytokine release through humanized monoclonal antibodies was moderate and selective : anti-CD25 led to increased release of IL-2 and reduced production of TNFalpha , whereas anti-CD3 decreased release of interferon-y and IL-5 and increased secretion of IL-10
Shaw et al., J Pharmacol Exp Ther 2009 : In summary, TNFalpha acts through p55 and p75 receptors to precipitate an innocuous inflammatory cascade
Muñoz-Fernández et al., Eur J Immunol 1990 : By contrast, TNF strongly increased the membrane level of CD25 and to a lesser extent that of the activation antigen, 4F2, over the levels already induced by phorbol esters on T cells ... More interestingly, TNF significantly increased the number of high-affinity IL2R on purified T cells in the presence of phorbol 12,13-dibutyrate
Vink et al., Eur J Immunol 1990 : In accordance with these observations, IL6 and to a lesser extent TNF were found to enhance IL2R expression by CD8 cells
Chouaib et al., Proc Natl Acad Sci U S A 1988 : Immunofluorescence analysis revealed that IL-2/TNF selectively up-regulated Tac antigen expression on LAK precursors
Panzer et al., Clin Exp Immunol 1993 : We show in this system that exogenously added IL-1 beta, IL-6 and TNF-alpha induces IL-2 receptor (R) up-regulation and IL-2 production, and proliferation by both CD4+ and CD8+ cells
Benigni et al., J Immunol 1996 : These data indicate that p55 plays a major role in TNF activation of the hypothalamus-pituitary-adrenal axis and in the centrally mediated induction of peripheral IL-6 by TNF, but p75, despite having little IL-6 inductive properties by itself, seems to potentiate p55 induction of IL-6
Ueta et al., Eur J Immunol 1996 : Furthermore, IL-12 up-regulated TNF receptors on gammadelta T cells in vitro : TNF-alpha binding to its receptor induced CD25 expression on the gammadelta T cells in an autocrine or paracrine fashion, or perhaps both
Peschon et al., J Immunol 1998 (Acute-Phase Reaction...) : We have examined the roles of p55 and p75 in mediating and modulating the activity of TNF in vivo by generating and examining mice genetically deficient in these receptors