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IL2RA — TNF
Text-mined interactions from Literome
Kim et al., Anticancer Res 2002
(Colonic Neoplasms) :
In contrast, during the 18- to 36-hours interval,
SL-TNF-alpha induced significantly higher ( p < 0.05 ) leukoctyte, T cell, and NK cell numbers, basal leukocyte proliferation, and
CD25+ activation marker expression ; the modulation occurred primarily in the spleen
Tchórzewski et al., Med Sci Monit 2005
(Autoimmune Diseases...) :
We analyzed reactive oxygen intermediate ( ROI ) production by peripheral blood granulocytes, the production of IL-2, IL-5, IL-10, IL-12, and
TNF-alpha cytokines by lymphocytes, and the
activation of
CD25 , CD26, CD69, CD71, and HLA DR antigen expression
Barten et al., Transplant Proc 2005
(Gingival Diseases...) :
Compared to CsA therapy, increased TRL concentrations did not further inhibit PCNA expression,
inhibited CD25 expression less on days 1 and 2 and equally high on day 3, but inhibited expression of IL-2 and
TNF-alpha significantly higher on days 2 and 3 ( P < .05 )
Schrepfer et al., Transplant Proc 2006
:
TNF-alpha stimulation and TCR/CD28 co-stimulation significantly
increased EC ICAM-1/VCAM-1-expression and LC
CD25 surface expression, respectively
van de Linde et al., Hum Immunol 2006
(Diabetes Mellitus, Type 1) :
Modulation of cytokine release through humanized monoclonal antibodies was moderate and selective :
anti-CD25 led to increased release of IL-2 and reduced production of
TNFalpha , whereas anti-CD3 decreased release of interferon-y and IL-5 and increased secretion of IL-10
Shaw et al., J Pharmacol Exp Ther 2009
:
In summary,
TNFalpha acts through
p55 and p75 receptors to precipitate an innocuous inflammatory cascade
Muñoz-Fernández et al., Eur J Immunol 1990
:
By contrast,
TNF strongly
increased the membrane level of
CD25 and to a lesser extent that of the activation antigen, 4F2, over the levels already induced by phorbol esters on T cells ... More interestingly,
TNF significantly
increased the number of high-affinity
IL2R on purified T cells in the presence of phorbol 12,13-dibutyrate
Vink et al., Eur J Immunol 1990
:
In accordance with these observations, IL6 and to a lesser extent
TNF were found to
enhance IL2R expression by CD8 cells
Chouaib et al., Proc Natl Acad Sci U S A 1988
:
Immunofluorescence analysis revealed that
IL-2/TNF selectively
up-regulated Tac antigen expression on LAK precursors
Panzer et al., Clin Exp Immunol 1993
:
We show in this system that exogenously added IL-1 beta, IL-6 and
TNF-alpha induces
IL-2 receptor (R) up-regulation and IL-2 production, and proliferation by both CD4+ and CD8+ cells
Benigni et al., J Immunol 1996
:
These data indicate that
p55 plays a major role in
TNF activation of the hypothalamus-pituitary-adrenal axis and in the centrally mediated induction of peripheral IL-6 by TNF, but p75, despite having little IL-6 inductive properties by itself, seems to potentiate p55 induction of IL-6
Ueta et al., Eur J Immunol 1996
:
Furthermore, IL-12 up-regulated TNF receptors on gammadelta T cells in vitro
: TNF-alpha binding to its receptor
induced CD25 expression on the gammadelta T cells in an autocrine or paracrine fashion, or perhaps both
Peschon et al., J Immunol 1998
(Acute-Phase Reaction...) :
We have examined the
roles of
p55 and p75 in mediating and modulating the activity of
TNF in vivo by generating and examining mice genetically deficient in these receptors