Gene interactions and pathways from curated databases and text-mining

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IL4 — IRF6

Text-mined interactions from Literome

Schytte Blix et al., J Periodontal Res 1999 (Aggressive Periodontitis...) : We have studied the effect of lipopolysaccharide (LPS) extracted from these periodontopathogenic bacteria on synthesis of the proinflammatory cytokines, interleukin-1beta(IL-1beta) , tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and the anti-inflammatory cytokine IL-1 receptor antagonist (IL-1ra) in human whole blood
Nishikage et al., J Hepatol 1999 (Drug-Induced Liver Injury) : LPS inhibited Con-A hepatitis by inducing IL-6 and thereby inhibited IL-4 synthesis from NK1+ T cells
Schrader et al., J Exp Med 1999 : Splenic B cells from mice deficient in Msh2, Mlh1, Pms2, or Mlh1 and Pms2 were stimulated in culture with lipopolysaccharide (LPS) to induce immunoglobulin ( Ig ) G2b and IgG3, LPS and interleukin (IL)-4 to induce IgG1, or LPS, anti-delta-dextran, IL-4 , IL-5, and transforming growth factor (TGF)-beta1 to induce IgA
Iwagaki et al., Infect Immun 2000 : The purpose of this study was to compare and contrast the endotoxin neutralizing activities of two synthetic antiendotoxin peptides ( SAEP-2 and SAEP-4 ), PMB, and an LPS core-specific monoclonal antibody ( MAb ), WN1 222-5, based on their abilities to inhibit CD14 mediated target cell uptake of fluorescein isothiocyanate ( FITC ) -conjugated LPS, detected by flow cytometry and confocal microscopy, and LPS induced production of the proinflammatory cytokines, interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha), as measured by bioassays
Ledeboer et al., Glia 2000 : LPS induced levels of IL-1beta were suppressed by IL-10, but not by IL-4 and TGF-beta1/beta2
Pioli et al., J Immunol 2000 : Our results show that CD40 or LPS stimulation in the presence of IL-4 induces CTLA-4 expression in purified B cells ; the maximum level is reached in both membrane and intracellular compartments after 48-72 h. Engagement of the B cell CTLA-4 by immobilized mAb inhibits IgG1 and IgE production and reduces the frequency of IgG1- and IgE expressing B cells
Stassen et al., J Immunol 2001 : Herein we report that in primary murine bone marrow derived mast cells activated with ionomycin or IgE-Ag the bacterial endotoxin LPS strongly enhances the expression of IL-9 and IL-13, but not IL-4
Carroll et al., Am J Vet Res 2001 : Serum prolactin (PRL) concentration was decreased in pigs at 18 C, compared with pigs at 34 C. Challenge with LPS resulted in an increase in serum PRL concentration at 18 C but had no effect on serum PRL at 34 C. Challenge with LPS resulted in an increase in expression of tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 receptor mRNA in the hypothalamus
Panerai et al., Diabetologia 2001 (Diabetes Mellitus, Type 1...) : Anti-CD3 and/or lipopolysaccharide (LPS) induced blood levels of interferon (IFN)-gamma, interleukin (IL)-4, IL-10, IL-12 and tumour necrosis factor (TNF)-alpha were measured by ELISA in 10 week-old female NOD mice treated for 6 consecutive weeks with either MFP14 or PBS
Zähringer et al., J Endotoxin Res 2001 : In human mononuclear cells ( hMNC ) the new LA ( tetra ) antagonized LPS induced release of interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor (TNF) in a dose dependent manner with identical antagonistic potency as compared with compound 406
Nakajima et al., J Neurochem 2002 : C8-ceramide as well as LPS enhanced the production/secretion of BDNF but, different from LPS, did not induce tumor necrosis factor alpha, interleukin-1beta , or nitric oxide
Pilette et al., J Immunol 2002 : In contrast, IL-4 , which exerts a similar inhibitory effect on the oxidative burst and TNF-alpha release by monocytes, acts primarily through a down-regulation of LPS receptors
Swinney et al., J Biol Chem 2002 : Ro106-9920 blocked lipopolysaccharide (LPS) dependent expression of TNFalpha, interleukin-1beta , and interleukin-6 in fresh human peripheral blood mononuclear cells with IC ( 50 ) values below 1 microm
Bonder et al., Cytokine 2002 : While IL-4 can suppress LPS induced interleukin beta ( IL-beta ) and tumour necrosis factor alpha (TNF-alpha) production by monocytes, IL-4 can suppress LPS induced IL-1 beta, but not TNFalpha production by the more differentiated cells
Armstrong et al., J Vet Pharmacol Ther 2002 : Production of the cytokines interleukin-1 (IL-1), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) in response to lipopolysaccharide (LPS) , and the effects of addition of carprofen ( racemate and R and S enantiomers ) were determined
Aikawa et al., Inflamm Res 2002 (Leukemia, Monocytic, Acute) : T-614 inhibited LPS stimulated production of TNF-alpha, interleukin (IL)-6, and IL-8 in a concentration dependent manner with decreasing mRNA levels ( IL-6 and IL-8 )
Li et al., Acta Pharmacol Sin 2002 (Arthritis, Experimental) : To investigate the effects of leflunomide ( LEF ) on modulating interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor- alpha (TNF-alpha) production induced by lipopolysaccharide (LPS) in peritoneal macrophages ( PMphi ) in adjuvant arthritis rats and elucidate the possible mechanisms of antiinflammatory and antirheumatoid effects of LEF
Zhu et al., J Leukoc Biol 2002 : With DC preparations obtained from murine bone marrow cultured in granulocyte macrophage-colony stimulating factor, the Ps ODN blocked the production of interleukin-12 and nitric oxide induced by bacterial DNA, an immunostimulatory cytosine phosphate guanosine dinucleotide ( CpG ) ODN and lipopolysaccharide (LPS)
Shinkai et al., Reproduction 2003 (Obstetric Labor, Premature...) : LPS induced premature delivery and an increase in prostaglandin F ( 2alpha ) ( PGF ( 2alpha ) ), interleukin 1alpha (IL-1alpha), IL-6 and IL-10 in the amniotic fluid, and an increase in IL-6 in plasma
Hinz et al., Biochem Biophys Res Commun 2003 (Inflammation) : Stimulation of cells with LPS resulted in a profound induction of the expression of COX-2, interleukin (IL)-1, IL-6, tumor necrosis factor (TNF), and granulocyte-macrophage colony stimulating factor ( GM-CSF )
Park et al., J Neurochem 2003 (Inflammation) : We observed that ( i ) chloroquine augmented LPS induced expression of pro-inflammatory cytokines such as lymphotoxin (LT)-beta, tumor necrosis factor (TNF)-alpha, interleukin (IL)-1alpha, IL-1beta and IL-6 in human astroglial cells, while the same treatment suppressed LPS induced expression of cytokines in monocytic and microglial cells ; ( ii ) chloroquine alone induced expression of pro-inflammatory cytokines in a dose- and time dependent manner in astroglial cells ; ( iii ) other lysosomotropic agents such as ammonium chloride and bafilomycin A1 had minimal effects on cytokine expression ; and ( iv ) chloroquine induced the activation of nuclear factor-kappa B in astroglial cells, which is a required component of chloroquine induction of cytokines
Kohut et al., J Am Coll Nutr 2003 : LPS induced production of IL-1beta, and PHA induced IL-2, IL-4 , IL-10, or IFN-gamma production was not altered by the supplement
Giri et al., J Neurosci 2004 (Inflammation) : A pharmacological activator of AMPK, 5-amino-4-imidazole carboxamide riboside ( AICAR ) inhibited lipopolysaccharide (LPS) induced expression of proinflammatory cytokines ( tumor necrosis factor alpha, interleukin-1beta , and interleukin-6 ) and inducible nitric oxide synthase in primary rat astrocytes, microglia, and peritoneal macrophages
Shin et al., J Ethnopharmacol 2004 (Fatigue Syndrome, Chronic) : KBT ( 1 mg/ml ) significantly inhibited LPS induced tumor necrosis factor-alpha, interleukin-10 , and transforming growth factor-beta1 production in PBMC of CFS patients
Fiebich et al., Phytomedicine 2004 : The Salix extract inhibited the LPS induced release of tumor necrosis factor-alpha, interleukin-1beta and interleukin-6 with IC50-values of 180.0, 33.0 and 86.0 microg/ml, respectively
Ishizuka et al., J Immunol Methods 1992 : Stimulation of the cultures with LPS significantly increased IL-4 production in two of six patient PBMC cultures but in none of the control cultures ; stimulation with Con A markedly increased IL-4 production in all patient PBMC cultures but in only two of seven control cultures
Herbert et al., FEBS Lett 1992 : IL-4 inhibits LPS- , IL-1 beta- and TNF alpha induced expression of tissue factor in endothelial cells and monocytes
Shin et al., FEBS Lett 2004 (Inflammation) : Furthermore, the compound inhibited not only LPS induced expressions of tumor necrosis factor-alpha, interleukin (IL)-1beta , IL-6 and inducible nitric oxide synthase and cyclooxygenase-2 but also LPS induced apoptosis of the RAW 264.7 cells
Arai et al., J Biol Chem 2004 : Our results indicate that the neurotoxic effects of LPS on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1beta , and caspase-11 expression in mice
Paintlia et al., J Neurosci Res 2004 (Demyelinating Diseases...) : Intraperitoneal pretreatment of pregnant female rats with NAC ( 50 mg/kg ), 2 hr prior to administration of LPS at embryonic day 18 ( E18 ), attenuated the LPS induced expression of inflammatory cytokines such as tumor necrosis factor-alpha, interleukin-1beta , and inducible nitric oxide synthase in fetal rat brains
Newport et al., Tuberculosis (Edinb) 2004 (Genetic Predisposition to Disease...) : LPS induced tumour necrosis factor, interleukin-1 beta and interleukin-10 production was not influenced by TLR4 Asp299Gly genotype
Eslick et al., Inflammation 2004 : In contrast, IL-4 and IL-10 inhibit LPS or IL-1beta induced pro-inflammatory cytokine production
Chien et al., Chin J Physiol 2004 : Our results indicated that ( 1 ) LPS stimulated pHi elevation was PKC dependent ; ( 2 ) After 30 min stimulation, LPS increased PLD activity via a measured production of 3H-phosphatidylethanol from phosphatidic acid and the initiation of PLD1a mRNA expression started ; ( 2 ) LPS stimulated IL-2 R expression but not IL-2 and IL-4 secretion
Thirunavukkarasu et al., J Cell Physiol 2005 : LPS stimulated the synthesis of TNF-alpha, interleukin (IL)-6, and IL-1beta but not of TGF-beta in qHSCs
Park et al., Biochemistry 2005 : Inhibition of NF-kappaB by cobrotoxin resulted in reductions in the LPS induced expressions of COX-2, iNOS, cPLA(2), IL-4 , and TNF-alpha in astrocytes and in COX-2 expression induced by SNP, LPS, and TNF-alpha in astrocytes
Norata et al., J Intern Med 2005 (Carotid Stenosis) : Furthermore, we investigated whether monocyte from D299G to T399I subjects present a defective response to CD40, interleukin (IL)-6 , monocyte chemotactic protein (MCP)-1, cyclo-oxygenase (COX)-2 and PTX3 expression induced by lipopolysaccharide (LPS)
Francey et al., Vet Immunol Immunopathol 1992 : LPS triggering promoted the secretion of interleukin-1 , as evidenced by measurement of murine thymocyte costimulatory activity, and transforming growth factor-beta
Kim et al., Antioxid Redox Signal 2005 (Inflammation) : The LPS induced expression of inducible proinflammatory genes such as inducible NO synthase, interleukin (IL)-1beta , IL-6, and granulocyte-macrophage colony stimulating factor was significantly abolished ( IRs=99.1 %, 74.6 %, 74.0 %, and 64.4 %, respectively ) by aframodial
Duramad et al., J Appl Toxicol 2006 : Human blood cultures were treated with CPF/CPO/TCP ( 1-1000 microg ml(-1) ) and LPS ( 1.5-2.5 microg ml(-1) ) or Der p1 ( 200 AU ml(-1) ) and supernatants were collected at 48 h. Pesticides CPF, CPO and TCP did not induce cytokine expression in vitro, while LPS and Der p1 induced IFN-gamma and IL-4 expression, respectively
Suzuki et al., Biomed Pharmacother 2006 : Using enzyme linked immunosorbent assays ( ELISAs ) we showed DHMEQ to inhibit LPS induced secretion of IL-6, IL-12, interleukin-1beta (IL-1beta), and TNF-alpha
Spertini et al., J Immunol 1991 : Expression of the LAM-1 ligand by endothelium was optimally induced by LPS and the proinflammatory cytokines TNF-alpha and IL-1 beta, whereas IFN-gamma and IL-4 induced lower levels of expression
Nagarajan et al., J Immunol 2007 : In this study, we demonstrate that mouse NKT cells are activated in response to Escherichia coli LPS , and produce IFN-gamma, but not IL-4 , although activation through their TCR typically induces both IL-4 and IFN-gamma production
Hadley et al., Shock 2007 (Inflammation) : At the end of CPB, ex vivo production of tumor necrosis factor alpha, interleukin (IL) 1beta, IL-8, and IL-10 in response to PepG or LPS was virtually abolished ( P < 0.05 )
Sakata et al., Immunology 2007 (Disease Models, Animal...) : We report here the effects of the most potent SMase inhibitor, SMA-7, on the LPS mediated release of tumour necrosis factor-alpha, interleukin-1beta and interleukin-6 from THP-1 macrophages and the pathology of dextran sulphate sodium (DSS) induced colitis in mice
Shui et al., Rheumatology (Oxford) 2007 (Disease Models, Animal...) : First, it is not known whether LPS can stimulate mesangial cells (MCs) to secrete the pro-inflammatory cytokine, interleukin (IL)-18
Simon et al., Br J Dermatol 2007 (Dermatitis, Atopic) : LPS stimulation blocked the increased spontaneous production of IL-4 and IL-5 by PBMC from AD patients, but had no effect on IL-13 production
Boos et al., Am J Cardiol 2007 (Atrial Fibrillation...) : Effects of LPS on high-sensitivity C-reactive protein, interleukin-6 , tumor necrosis factor-alpha, and neutrophil counts as indexes of an inflammatory response were also assessed ... LPS led to overall marked increases in high-sensitivity C-reactive protein, interleukin-6 , tumor necrosis factor-alpha, and neutrophil counts ( all p < 0.0001 ) and an average temperature increase of 1.1 degrees C
Kim et al., Arch Pharm Res 2007 (Periodontitis) : LPS enhanced ROS production, as well as, expression of pro-inflammatory cytokines such as interleukin-1beta, interleukin-6 , interleukin-8 and tumor necrosis factor-alpha, and the production and activation of MMP2
Santander et al., Biomedica 2007 (Chagas Disease) : KMP-1 1 protein does not affect the maturation of dendritic cells, but in the presence of LPS the K1 peptide leads to a decreased expression of CD86 and CD83 as well as interleukin-12 production, This phenomenon may be associated with an impaired T cell stimulation
Hughes et al., Circ Res 2008 (Inflammation) : Pretreatment of macrophages with 500 nmol/L S1P markedly reduced LPS mediated secretion of tumor necrosis factor-alpha, monocyte chemoattractant protein-1, and interleukin-12
Motoyoshi et al., Neurochem Int 2008 (Gliosis...) : Both AmB and LPS also induced mRNA expressions of interleukin-1beta, interleukin-6 , and tumor necrosis factor-alpha in microglia
Chochi et al., Clin Cancer Res 2008 (Helicobacter Infections...) : H. pylori LPS induced neither interleukin-12 nor IFN-gamma production by MNC, although E. coli LPS did induce production of both significantly
Gupta et al., Am J Reprod Immunol 2008 (Neoplasms, Experimental) : The MO-DC obtained from male mice showed a better response to GM-CSF and IL-4 treatment and activation by LPS for differentiating into cells with DC phenotype compared with that of female mice
Hollenbach et al., Biochem Pharmacol 2008 : In contrast, both EP and EL were shown to suppress the Lipopolysaccharide (LPS) induced production of pro-inflammatory cytokines such as tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6 and IL-8 from human immunocompetent cells, and modulated the expression of the immune receptors HLA-DR, CD14 and CD91 on human monocytes
Reikeras et al., J Trauma 2009 (Hip Injuries) : Ex vivo lipopolysaccharide (LPS) and peptidoglycan ( PepG ) induced tumor necrosis factor-alpha (TNF-alpha) and interleukin ( IL-10 ) releases were measured in whole blood sampled preoperatively and added serum taken before, at the end of operation and at postoperative day 1 and 6
Fock et al., J Nutr Sci Vitaminol (Tokyo) 2008 (Anemia...) : In this study, we examined the production of Interleukin-4 (IL-4) and IL-10 in response to lipopolysaccharide (LPS) and also evaluated the cellularity of the blood, bone marrow, and spleen in a mouse model of protein-energy malnutrition
Tewtrakul et al., J Ethnopharmacol 2009 : The extract of Garcinia mangostana together with alpha- and gamma-mangostins were tested for anti-inflammatory effect against lipopolysaccharide (LPS) induced nitric oxide ( NO ), prostaglandin E2 ( PGE2 ), tumor necrosis factor alpha (TNF-alpha) and interleukin-4 (IL-4) releases as well as their mechanisms in transcriptional levels using RAW264.7 macrophage cells
Walton et al., Am J Physiol Gastrointest Liver Physiol 2009 : LPS induced secretion of prostaglandin E2 ( PGE2 ), interleukin (IL)-6 , and keratinocyte derived chemokines ( KC ) was measured by ELISA
Avni et al., Immunol Lett 2009 (Inflammation) : In this study we thus investigated the effect of PCERA-1 on LPS induced release of TNFalpha, interleukin (IL)-10 and IL-12p40, in vivo, and ex vivo
Burstein et al., J Immunol 1991 : IL-4 increases the quantity of IgE produced by transgenic derived B cells in response to LPS stimulation
Zemans et al., Cell Immunol 2009 : Furthermore, LPS induced actin polymerization as well as MCP-1, tumor necrosis factor-alpha, interleukin-6 , and interleukin-1beta expression are dependent on Tec kinase activity
Ozcan et al., J Allergy Clin Immunol 2009 : Purified mouse naive B cells were stimulated with the TACI ligand a proliferation inducing ligand (APRIL) and with suboptimal concentrations of the TLR4 ligand LPS in the presence or absence of IL-4
Ishikawa et al., Genetic vaccines and therapy 2009 : The ability of splenic cells to produce IFN-gamma and IL-4 upon in vitro stimulation with LPS or S. aureus and the serum titer of specific IgG1 and IgG2a anti-hsp65 antibodies after intramuscular immunization with pVAXhsp65 was then tested
Suo et al., J Ethnopharmacol 2009 : Moreover, the effects of MT on soluble intercellular adhesion molecule-1 ( sICAM-1 ), interleukin-6 (IL-6) and interleukin-8 (IL-8) production induced by lipopolysaccharide (LPS) in these cells were evaluated
Mukherjee et al., J Biol Chem 2009 : Silencing of myeloid differentiation protein ( MyD88 ) and TRIF related adaptor molecule ( TRAM ), using small interfering RNA abolished IL-4 induction induced by LPS whereas silencing of TRAM has no effect on TNFalpha induction, thereby indicating that LPS induced TNFalpha is MyD88 dependent but IL-4 is required both MyD88 and TRAM
Novem et al., Clinical and vaccine immunology : CVI 2009 : In this study, the biological activities of B. pseudomallei LPS were compared to those of Burkholderia thailandensis LPS, and it was found that both murine and human macrophages produced levels of tumor necrosis factor alpha, interleukin-6 (IL-6), and IL-10 in response to B. pseudomallei LPS that were lower than those in response to B. thailandensis LPS in vitro
Asghar et al., American journal of physiology. Renal physiology 2009 (Hypertension...) : We found that LPS increased the levels of inflammatory cytokines, interleukin-6 , and tumor necrosis factor-alpha in the rats given either normal- or high-salt intake
Inaba et al., J Nat Med 2010 (Arthritis, Experimental) : HP-ext dose-dependently suppressed the lipopolysaccharide (LPS) induced production of inflammatory cytokines [interleukin-1beta ( IL-1beta ), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) ] in mouse macrophage cells ( RAW 264.7 )
Wren et al., Cancer Genet Cytogenet 2010 (Leukemia, Lymphocytic, Chronic, B-Cell) : A range of culture techniques for conventional cytogenetic ( CC ) analyses was compared : 24-hour unstimulated, 72 hours incubation with additional fetal calf serum, 72 hours stimulation with interleukin 4 , 72 hours stimulation with lipopolysaccharide (LPS) , 72 hours stimulation with TPA ( 12-O-tetradecanoylphorbol 13-acetate ), and 72 hours stimulation with CpG-oligonucleotide DSP30 + Interleukin-2 (IL-2)
Cheng et al., J Ethnopharmacol 2010 : Treatment with BPs enhanced phagocytic functions of macrophages ( phagocytosis of apoptotic thymocytes, IgG opsonized sheep red blood cells and chicken red blood cells ) and inhibited LPS induced productions of NO and proinflammatory cytokines ( interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha )
Yu et al., Phytother Res 2011 (Inflammation) : PA significantly inhibited the LPS induced production of nitric oxide ( NO ), interleukin-1ß (IL-1ß) and tumor necrosis factor-a (TNF-a)
Bagnasco et al., J Endocrinol Invest 1990 : The following variables were evaluated : T cell proliferation following stimulation with phytohemagglutinin ( PHA ), and anti-CD3 or anti-CD2 monoclonal antibodies ; interleukin-2 (IL-2) and gamma-interferon ( gamma-IFN ) production by PHA stimulated T cells in bulk culture and by T cell clones ; PHA induced IL-2 receptor expression ; LPS induced interleukin-1 production by accessory cells
Xin et al., Cell Biochem Funct 2011 : To determine if microglial cells, a subset of glial cells, are involved in asymmetric production, interleukin-6 (IL-6), interleukin-1ß (IL-1ß) and nitric oxide ( NO ) responses to LPS by microglial cells in the right and left cerebral cortices were examined
Tavano et al., J Innate Immun 2011 : Suboptimal stimulatory doses ( 5-10 µM ) of apidaecin partially inhibited the lipopolysaccharide (LPS) induced increase in major histocompatibility complex class II ( MHCII ) and CD86 in macrophages, and the release of selected cytokines/chemokines by both macrophages [ interleukin (IL)-6 and tumor necrosis factor (TNF)-a ] and monocytes [IL-6, TNF-a, basic fibroblast growth factor (FGF) and eotaxin ]
Liu et al., Neurol Res 2011 : Both the LPS and amyloid-beta peptide enhanced interleukin 1, interleukin 6, and tumor necrosis factor-alpha synthesis and these effects were inhibited by 10 ( -9 ) M coumestrol
Choi et al., Biol Pharm Bull 2011 : Cornuside significantly inhibited the LPS induced production of nitric oxide, prostaglandin E ( 2 ), tumor necrosis factor-alpha, interleukin-6 (IL-6), and IL-1beta
Hung et al., Am J Chin Med 2011 (Drug-Induced Liver Injury...) : Our results showed that ES reduced LPS induced nitric oxide ( NO ), interleukin (IL)-1 , IL-6, reactive oxygen species ( ROS ), and prostaglandin ( PGE ( 2 ) ) production in BV-2 cells
Kushawaha et al., J Immunol 2011 (Disease Models, Animal...) : Further, rLelF-2 downregulated LPS induced IL-10 as well as soluble L. donovani Ag-induced IL-4 production by Leishmania patient PBMCs
Uto et al., Int Immunopharmacol 2012 : Among these jolkinolides, 17-hydroxy-jolkinolide B ( HJB ) exhibited the most potent inhibition of LPS induced production of inflammatory mediators such as prostaglandin E ( 2 ) ( PGE ( 2 ) ), nitric oxide ( NO ), and pro-inflammatory cytokines [ interleukin-6 (IL-6) and tumor necrosis factor-a (TNF-a) ]
Yu et al., Inflammation 2012 (Inflammation) : Pyranocoumarins significantly inhibited LPS induced production of nitric oxide, interleukin-6 (IL-6), and tumor necrosis factor-a (TNF-a)
Zhu et al., Zhong Xi Yi Jie He Za Zhi 1990 : When the drug was added from 0.6 mg/ml to 5 mg/ml a significant dose dependent inhibition effect was shown in the following immune reactions of mice ( P less than 0.05-0.01 ) : phagocytic function of peripheral blood leucocytes assayed by chemiluminescence ; mitogenic response of spleen lymphocytes to Con A ; mixed lymphocyte culture and LPS induced interleukin-1 release of macrophages
Zhang et al., Phytochemistry 2012 : E. paradoxa var. paradoxa, rich in polyenes/polyacetylenes, was an especially efficient inhibitor of LPS induced production of nitric oxide ( NO ), prostaglandin E2 ( PGE2 ), interleukin-1 beta ( IL-1ß ) and interleukin-6 (IL-6) by 46 %, 32 %, 53 % and 26 %, respectively, when tested at 20 µg/ml in comparison to DMSO control
Seo et al., Immunopharmacol Immunotoxicol 2012 (Inflammation) : SPEE treatment significantly inhibited the LPS induced production of NO, prostaglandin E ( 2 ), interleukin-6 , and tumor necrosis factor-a and inhibited the expression of iNOS and COX-2 via attenuation of NF-?B p65 expression
Zhu et al., PloS one 2012 : Our results show that artemisinin significantly inhibited LPS induced production of tumor necrosis factor-alpha ( TNF-a ), interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1) and nitric oxide ( NO )
Reyes et al., Eur J Nutr 2013 (Inflammation) : Calcium induced thromboxane B ( 2 ) and nitric oxide production, LPS induced prostaglandin E ( 2 ) and nitric oxide production and LPS induced interleukin 1ß production were measured
Holen et al., Fish Shellfish Immunol 2012 : LPS cell activation increased mRNA expression of interleukin 8 ; interleukin-1ß ; cyclooxygenase 2 ; leukocyte derived chemotaxin 2 ; carboxyl-esterase 2 and environmental biomarker cytochrome P450 1A
Hebeda et al., Arch Toxicol 2012 : Hydroquinone treatment impaired LPS induced nitric oxide ( NO ), tumour necrosis factor a (TNF-a), interleukin (IL)-1ß and IL-6 secretions by neutrophils
Rajan et al., Spine (Phila Pa 1976) 2013 : LPS stimulation resulted in significant increases in tumor necrosis factor a (TNF)-a, interleukin (IL)-1ß, IL-6, and nitric oxide levels and significant inhibition in aggrecan and collagen-2
Sulyok et al., Br J Anaesth 2012 (Colorectal Neoplasms...) : The following parameters were measured : lipopolysaccharide (LPS) induced tumour necrosis factor (TNF)-a, procalcitonin ( PCT ), interleukin (IL)-6/10, heat shock proteins ( HSPs ) 60, 70, and 90, human leucocyte antigen-DR ( HLA-DR ), and LPS binding protein (LBP)
Qin et al., J Immunol 2012 (Inflammation) : The M1 proinflammatory phenotype is induced by LPS , IFN-?, and GM-CSF, and IL-4 , IL-13, and M-CSF induce anti-inflammatory M2 macrophages
Byun et al., Biochem Biophys Res Commun 2012 (Inflammation) : In addition, EGCG treated DCs inhibited lipopolysaccharide (LPS) induced production of pro-inflammatory cytokines ( tumor necrosis factor [TNF ] -a, interleukin [ IL]-1ß, and IL-6 ) and activation of mitogen activated protein kinases ( MAPKs ), e.g., extracellular signal regulated kinase 1/2 ( ERK1/2 ), p38, c-Jun N-terminal kinase (JNK), and nuclear factor ?B ( NF-?B ) p65 translocation through 67LR
Zhang et al., Bioorg Med Chem 2012 : The lead compound 1 ( NCI126224 ) was found to suppress LPS induced production of nuclear factor-kappaB ( NF-?B ), tumor necrosis factor ( TNF-a ), interleukin-1ß (IL-1ß), and nitric oxide ( NO ) in the nanomolar-low micromolar range
Jung et al., Arterioscler Thromb Vasc Biol 2012 : Eicosapentaenoic acid alone or with LPS blunted LPS mediated stimulation of macrophage proinflammatory interleukin-6, interleukin-12p40 , and toll-like receptor-4 mRNA and increased anti-inflammatory interleukin-10 and mannose receptor mRNA
La Flamme et al., PloS one 2012 : We found that although both WT and IL-4Ra-deficient macrophages could be classically activated by LPS or type II activated by immune complexes plus LPS, IL-4Ra-deficient macrophages consistently produced much higher levels of IL-12p40 and IL-10 than WT macrophages
Hsiang et al., Food Chem 2013 (Inflammation) : In vivo and ex vivo imaging showed that LPS increased NF-?B luminescence in the abdominal region, which was significantly inhibited by TS or GA. Immunohistochemical and ELISA analyses confirmed that TS and GA inhibited LPS induced NF-?B, interleukin-1ß , and tumour necrosis factor-a expression
Cheng et al., J Sci Food Agric 2013 (Inflammation) : PV inhibited LPS stimulated nitric oxide ( NO ), prostaglandin ( PG ) E ( 2 ), interleukin (IL)-1ß and tumour necrosis factor (TNF)-a release and inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 protein expression
Ro et al., Transplantation 2012 : Both polyriboinosinic polyribocytidylic acid and lipopolysaccharide (LPS) stimulation induced the mRNA expression of regulated and normal T cell expressed and secreted, interferon-?-inducible protein-10, monocyte chemotactic protein-1, interleukin-8 , and inducible nitric oxide synthase in murine islets, whereas the induction was attenuated in TRIF-KO, interferon-ß promoter stimulator-1-KO, and TLR4-KO mice
Daan de Boer et al., Am J Respir Cell Mol Biol 2013 (Asthma...) : LPS attenuated the production of Th2 cytokines ( IL-4 , IL-5, IL-10, and IL-13 ) in HDM challenged lungs, while enhancing the HDM induced release of IL-17, IL-33, IFN-?, and TNF-a
Kitagawa et al., Am J Physiol Gastrointest Liver Physiol 2013 (Reperfusion Injury) : In the experiment using isolated Kupffer cells, the expression of interleukin-6, interleukin-1ß , and endothelin-1 in response to LPS stimulation was attenuated by BCAA in a dose dependent fashion
Zhu et al., Biol Pharm Bull 2013 (MAP Kinase Signaling System) : Mollugin attenuated the LPS induced expression of nitric oxide ( NO ), inducible nitric oxide synthase (iNOS), interleukin (IL)-1ß and IL-6 but augmented the expression of tumor necrosis factor (TNF)-a
Chen et al., Food Chem Toxicol 2013 (Inflammation) : Both water and ethanolic extracts of I. suffruticosa significantly decreased LPS induced nitric oxide ( NO ) as well as the expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor-a, and pro-interleukin-1ß
Song et al., Eur J Pharmacol 2013 (Sepsis) : In RAW264.7 and mouse peritoneal macrophages, bis-N-norgliovictin dose-dependently inhibited LPS induced production of TNF-a, interleukin-6 (IL-6), interferon-ß ( IFN-ß ) and monocyte chemoattractant protein ( MCP-1 ), but without suppressing cell viability
Kang et al., Environ Toxicol Pharmacol 2013 (Inflammation) : It was demonstrated that LPS can induce the production of pro-inflammatory cytokines such as interleukin-1ß (IL-1ß), interleukin-6 (IL-6), and tumor necrosis factor-a (TNF-a) as well as the expression of inflammatory mediators as cyclooxygenase-2 (COX-2), and inducible nitric oxide synthases (iNOS) from HepG2 cells
Li et al., Zhong Nan Da Xue Xue Bao Yi Xue Ban 2013 : To observe the expression of progesterone receptor (PR), interleukin-1ß (IL-1ß), and cyclooxygenase-2 (COX-2) induced by lipopolysaccharide (LPS) or Toll-like receptor 4 antagonist ( TLR4 mAb ) in decidual cells in vitro, and then to explore the effect of LPS and its antagonist on PR of decidual cells and the relation between PR and inflammatory cytokines
Hu et al., Int J Mol Med 2013 : We found that GLGZD inhibited the inflammatory response in microglial cells as it significantly reduced LPS induced expression of pro-inflammatory nitric oxide, tumour necrosis factor-a, interleukin (IL)-6 and IL-1ß in BV-2 cells, in a dose dependent manner
Li et al., Mol Med Report 2013 (Acute Lung Injury...) : The upregulation of matrix metalloproteinase-9, interleukin (IL)-1ß , IL-6 and inducible nitric oxide synthase was induced by LPS in the mouse model of sepsis and the TC-1 cell line, and resveratrol suppressed the overexpression of these proinflammatory molecules in a dose-dependent manner
Olajide et al., Evidence-based complementary and alternative medicine : eCAM 2013 : Our results showed that cryptolepine significantly inhibited LPS induced production of tumour necrosis factor-alpha ( TNF a ), interleukin-6 (IL-6), interleukin-1beta ( IL-1 ß ), nitric oxide, and PGE2
Li et al., Eur J Pharmacol 2013 : Our data demonstrated that THC significantly inhibited LPS induced TNF-a, interleukin-6(IL-6) and nitric oxide ( NO ) production
Shin et al., Neurosci Lett 2013 (Inflammation) : NK-4 inhibited LPS induced upregulation of inducible NO synthase (iNOS), cyclooxygenase-2, interleukin-6, tumor necrosis factor-a, and interleukin-1ß in RAW264.7 cells in a time- and concentration dependent manner
Wu et al., Immunopharmacol Immunotoxicol 2013 : Materials and methods : We evaluated the effect of TBMS1 on LPS induced production of tumor necrosis factor (TNF)-a, interleukin (IL)-6 and IL-1ß in the culture supernatants of RAW 264.7 cells by enzyme linked immunosorbent assay
Cavaillon et al., Cell Immunol 1987 : Inhibition by gangliosides of the specific binding of lipopolysaccharide (LPS) to human monocytes prevents LPS induced interleukin-1 production
Kepron et al., J Immunol 1989 : Our results indicate that LPS alone induces rearrangement of the gamma 3 genes on both chromosomes whereas stimulation with LPS plus IL-4 results in deletion of gamma 3 genes and rearrangement of gamma 1 genes on both chromosomes
Lutzker et al., Cell 1988 : Furthermore, IL-4 inhibits LPS induction of germ-line gamma 2b transcripts in spleen cells and correspondingly abrogates switching to this CH gene
Sultzer et al., Infect Immun 1988 : DNA synthesis, polyclonal antibody synthesis, and interleukin-1 activity were stimulated by Bordetella pertussis LPS and Salmonella minnesota R595 LPS, although to a lesser extent than with responder cells
Ernst et al., J Clin Immunol 1986 (Acquired Immunodeficiency Syndrome) : In particular, we found a transient increase in C3b receptor mediated monocyte activation in ARC patients ; no influence of therapy on the otherwise intact LPS induced interleukin-1 production in vitro ; in some patients a transient corrective influence on the high pretherapeutic immunoglobulin secretion of B cells and their nonresponsiveness to pokeweed mitogen ; low T-cell responses to soluble antigens and alloantigens, which were partially restored during rIL-2 treatment in ARC patients and in one AIDS patient ; defective NK activity in PBMC of two AIDS patients, which was found to be restored when measured at the end of rIL-2 therapy ; and a rather constant phenotypic pattern of PBMC in each patient during therapy except for the decreasing proportion of OKT9 positive lymphocytes in AIDS patients, the increasing proportion of Leu8-Leu3a+ lymphocytes in all patients, and in particular, the transient significant decrease in the Leu7+/OKT3+ ratio, which pretherapeutically was very high in AIDS patients ( 0.78 +/- 0.21 ) and high in ARC patients ( 0.48 +/- 0.06 ) as compared to healthy controls ( 0.18 +/- 0.08 )
Cavaillon et al., Mol Immunol 1986 : Polymyxin-B inhibition of LPS induced interleukin-1 secretion by human monocytes is dependent upon the LPS origin
Billiar et al., Ann Surg 1988 : When cultured alone, Kupffer cells from these animals also produced more interleukin-1 ( p less than 0.002 ) and prostaglandin E2 ( PGE2 ) ( p less than 0.009 ) in response to LPS
Fujiwara et al., J Gen Microbiol 1988 : These LPS also enhanced interleukin-1 production by murine peritoneal macrophages and mouse cell line J744
Warren et al., Infect Immun 1988 : These data suggest that there may exist a self regulated mechanism for decreasing the toxicity of LPS and the production of LPS induced interleukin-1 ; this mechanism is controlled by a macrophage factor and functions through altering the binding of LPS to certain serum lipoproteins
Gallily et al., Cancer Immunol Immunother 1986 (Neoplasms, Experimental) : However, LPS induced interleukin 1 release was partially ( 55 % ) suppressed by embryonic fibroblast culture supernatant
Funk et al., Endocrinology 1994 : IL-4 , a prototypical antiinflammatory cytokine, also had a paradoxical effect on LPS induction of splenic PTHrP mRNA levels
Quentmeier et al., Leukemia 1995 (Leukemia, Monocytic, Acute) : Long-term LPS treatment apparently induced IL-4 responsiveness of the cell line
Clarke et al., Eur J Immunol 1995 : We investigated whether IL-4 could inhibit the up-regulation of kappa light chain and activation of NF kappa B by LPS in 70Z/3
Lundgren et al., Eur J Immunol 1995 : Smu-S gamma 1 switch recombination in lipopolysaccharide (LPS) + interleukin-4 (IL-4) activated mouse B cells was assayed by a digestion-circularization polymerase chain reaction
Fahmi et al., Cell Immunol 1993 : To achieve a better understanding of the mechanism of this type of desensitization, we studied the regulation of the production of interleukin 1, interleukin 6, and tumor necrosis factor alpha by mouse peritoneal macrophages in response to LPS , after a preliminary exposure to LPS or to structurally related synthetic lipids
Ramani et al., Br J Haematol 1993 : Moreover, IL-4 reduced LPS- and PMA induced TF mRNA levels
Purkerson et al., J Exp Med 1994 : Lipopolysaccharide (LPS) , in the presence of IL-4 , induced the accumulation of both S micro-S gamma 1 and S micro-S epsilon rearrangements, and cells treated with LPS exhibited 40-50-fold more S micro-S gamma 1 rearrangements than cells cultured with IL-5
Galdiero et al., Infect Immun 1993 (Salmonella Infections) : At higher concentrations ( 5 and 10 micrograms/ml, respectively ), LPS-R induces the maximal release of IL-6 from monocytes and the maximal release of IL-4 from lymphocytes
Mandler et al., J Immunol 1993 : We demonstrate that an anti-IgG1 antibody specifically and selectively inhibits IgE secretion ( approximately 70 % ) by LPS + IL-4 stimulated B cells, which provides functional evidence for mIgG1 expression by precursors of IgE secreting cells
Dokter et al., Blood 1993 : We studied the effect of interleukin-4 (IL-4) on the lipopolysaccharide (LPS) induction of two immediate early genes c-fos and c-jun
Daniel et al., Vet Immunol Immunopathol 1993 : While resting cells produced no detectable interleukin 1, stimulation with lipopolysaccharide (LPS) induced the production of biologically active interleukin 1
Sugiyama et al., Infect Immun 1996 : In contrast, LPS induced interleukin 1 activity in human gingival epithelial cells in culture, while LTA had little effect
Haraldsen et al., J Immunol 1996 : Notable disparities between the two endothelial test systems were that 1 ) expression of total cellular E-selectin ( but not surface membrane expression ) was sustained after 72 h of IL-1beta stimulation in HIMEC, contrasting a rapid biphasic response in HUVEC ; 2 ) LPS did not maintain prolonged expression of ICAM-1 and VCAM-1 in HIMEC ; and 3 ) VCAM-1 protein was dose-dependently up-regulated by IL-4 in HUVEC, peaking after 8 h, while IL-4 had only a negligible effect on the expression of this protein in HIMEC
Persoons et al., Am J Respir Cell Mol Biol 1996 : When alveolar macrophages were cultured, substantial amounts of interleukin-1(IL-1), interleukin-6 (IL-6), tumor necrosis factor alpha(TNF-alpha), and nitric oxide are produced upon stimulation with LPS
Hart et al., J Immunol 1996 (Arthritis, Rheumatoid) : Addition of an Ab to IL-10 suggested that the stimulatory effects of LPS on p75 TNF receptor expression were due, at least in part, to LPS stimulation of IL-10 production and that IL-4 acted , in part, by decreasing IL-10 production
Suttles et al., J Leukoc Biol 1996 : Recent studies have demonstrated that monocytes can be rescued from apoptosis via lipopolysaccharide (LPS) activation or stimulation with interleukin-1 or tumor necrosis factor-alpha
Jungi et al., Vet Immunol Immunopathol 1996 : LPS and IFN-gamma induce iNOS, IL-4 and TGF-beta down-regulate LPS or IFN-gamma induced iNOS
Hart et al., Immunology 1996 : In this study, activation of human monocytes by lipopolysaccharide (LPS) prevented concomitant IL-4 stimulation of MHC class II expression
West et al., Ann Surg 1997 : Macrophages incubated in CO2 produced significantly less TNF and interleukin-1 in response to LPS compared to incubation in air or helium
Sastre et al., Biochem J 1998 : In the present study we sought to determine : ( a ) whether macrophages ( cell line RAW 264.7 ) express ADC and agmatinase, and ( b ) if the enzymes are regulated by lipopolysaccharide (LPS) , and/or by the inhibitory cytokines transforming growth factor-beta ( TGF-beta ), interleukin-10 (IL-10) and interleukin-4 (IL-4)
Ju et al., Pharmacology 1998 (Disease Models, Animal...) : In the present study, we investigated the effects of esculentoside A on the production of tumor necrosis factor (TNF), interleukin-1 (IL-1) and interleukin-6 (IL-6) induced by lipopolysaccharide (LPS) in mice
Amura et al., Infect Immun 1998 (Sepsis) : These cells manifested markedly enhanced levels of in vitro TNF-alpha, interleukin 6 (IL-6), and nitric oxide production in response to LPS
Ma et al., Mol Pharmacol 1999 : IL-4 also inhibited the LPS induction, but to a lesser extent than IL-10