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CXCL12 — IL6
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Nanki et al., J Immunol 2001
(Arthritis, Rheumatoid) :
In this study we show that CCL2/monocyte chemotactic protein-1, CCL5/RANTES, and
CXCL12/stromal cell derived factor-1
enhanced IL-6 and IL-8 production by fibroblast-like synoviocytes ( FLS ) from patients with RA, and their corresponding receptors, CCR2, CCR5, and CXCR4, respectively, were expressed by RA FLS
Damås et al., Circulation 2002
(Angina, Unstable) :
In vitro,
SDF-1alpha ( 500 ng/mL )
reduced both unstimulated and endotoxin/mitogen stimulated mRNA and protein levels of monocyte chemoattractant protein-1,
interleukin-8 , matrix metalloproteinase-9, and tissue factor while increasing tissue inhibitor of metalloproteinases-1 in PBMC from patients with unstable angina
Koka et al., AIDS Res Hum Retroviruses 2003
(HIV Infections) :
IL-6 RNA levels in stroma also
increased somewhat with infection ; however, expression of
stromal cell derived factor 1 (SDF-1) by stromal elements was not affected
Chu et al., Carcinogenesis 2009
(Carcinoma, Basal Cell...) :
The mechanisms behind the
SDF-1alpha induced time and dose dependent upregulation of messenger RNA expression and protein secretion of
IL-6 were investigated ... The transcriptional
regulation of
IL-6 by
SDF-1alpha was mediated by phosphorylation of extracellular signal related kinase 1/2 and activation of the nuclear factor-kappaB complex
Blaine et al., J Orthop Res 2011
(Bursitis...) :
IL-6 caused a minimal but not statistically significant increase in
SDF-1a expression
Lai et al., Int J Gynecol Cancer 2011
(Genital Neoplasms, Female...) :
Similar treatment in HeLa cells caused increases in the mRNA levels of CCL2,
CXCL2 , IL-6, and IL-8, and in SKOV3 cells, mRNA levels of CCL2, CCL20, CXCL1, CXCL2,
IL-6 , and IL-8
increased
Lee et al., J Immunol 2012
:
CCR1 mediated STAT3 tyrosine phosphorylation and
CXCL8 expression in THP-1 macrophage-like cells
involve pertussis toxin-insensitive Ga ( 14/16 ) signaling and
IL-6 release