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BCL2 — IL7

Text-mined interactions from Literome

Hofmeister et al., Cytokine Growth Factor Rev 1999 : This protection is partly mediated by IL-7 induction of Bcl-2 , however other IL-7 induced events are probably also involved in the trophic response
Graninger et al., Cell Death Differ 2000 (Lupus Erythematosus, Systemic) : IL-2, IL-4, IL-7 and IL-15 led to a significant increase in Bcl-2 and a reduction in cell death rates, which was even more pronounced in SLE
Ducrey-Rundquist et al., J Virol 2002 : Furthermore, the phosphatidylinositol 3-kinase (PI3K) inhibitor wortmannin blocked IL-7 induced cell survival and Bcl-2 synthesis but had no effect on the acquisition of HIV susceptibility, suggesting that IL-7 induced HIV type 1 permissiveness is not mediated by the PI-3 K pathway and that, perhaps, the Jak/STAT5 pathway, the other known mediator of IL-7 triggered signaling in T cells, governs this process
Barata et al., J Exp Med 2004 (Precursor Cell Lymphoblastic Leukemia-Lymphoma) : PI3K activation was mandatory for IL-7 mediated Bcl-2 up-regulation, p27kip1 down-regulation, Rb hyperphosphorylation, and consequent viability and cell cycle progression of T-ALL cells
Yang et al., J Immunol 2008 : However, IL-7 induced expressions of Bcl2 family members ( Bcl2, Bcl-x ( L ), Bax, and Bad ) were similar between naive and memory cells
Faller et al., Int Immunol 2009 (HIV Infections) : Interestingly, while Tat acts synergistically with IL-7 to reduce CD127 expression, it antagonizes IL-7 induced cell proliferation and Ki-67 expression and has no effect on IL-7 mediated signal transducer and activator of transcription 5 ( STAT5 ) phosphorylation or expression of the anti-apoptotic gene Bcl-2
Kasten et al., Infect Immun 2010 (Disease Models, Animal...) : Next, IL-7 increased Bcl-2 expression in T cells isolated from septic mice as early as 3 h following treatment
Vranjkovic et al., J Leukoc Biol 2011 (HIV Infections) : In contrast, IL-7 induced Bcl-2 expression was not impaired in CD8 ( + ) CD127 ( + ) T cells from HIV ( + ) individuals
Lee et al., Oncogene 1996 (Lymphoma, T-Cell) : The expression of Bcl-2 protein was down-regulated when CS-21 cells were cultured alone, but the addition of IL-7 recovered the expression of Bcl-2
Banerjee et al., J Immunol 1998 (Cell Transformation, Viral) : IL-7 also delayed the decreases in the levels of c-Myc, Bcl-2, and Bcl-xL that occur upon loss of v-Abl kinase activity
Soares et al., J Immunol 1998 : IL-7 prevented the decrease in Bcl-2 and Bcl-xL and induced cell cycling in up to 20 % of cord T cells after 8 days, resulting in a threefold increase in cord T cell numbers