Gene interactions and pathways from curated databases and text-mining

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FASLG — IL8

Text-mined interactions from Literome

Selam et al., J Clin Endocrinol Metab 2002 (Endometriosis) : Regulation of fas ligand expression by IL-8 in human endometrium ... To test our hypothesis, we studied the in vitro regulation of FasL expression and apoptosis by IL-8 in endometrial cells
Duan et al., Clin Cancer Res 2004 (Osteosarcoma) : The purpose of these studies was to determine whether alkylating agents affect the expression of Fas ligand (FasL) and whether interleukin 12 enhances the sensitivity of human OS cells to alkylating agents
Kreuz et al., J Cell Biol 2004 : Moreover, down-regulation of both endogenous FLIP isoforms or of endogenous FLIPL alone was sufficient to enhance FasL induced expression of the NFkappaB target gene IL8
Imamura et al., J Biol Chem 2004 (Inflammation) : Fas ligand induces cell-autonomous NF-kappaB activation and interleukin-8 production by a mechanism distinct from that of tumor necrosis factor-alpha ... Here we found that FasL induces production of the inflammatory chemokine IL-8 without inducing apoptosis in HEK293 cells ... These results show that FasL induces NF-kappaB activation and IL-8 production by a novel mechanism, distinct from that of TNF-alpha
Trauzold et al., FASEB J 2005 (Adenocarcinoma...) : Stimulation of TRAF2 overexpressing cells with CD95 ligand led to induction of NF-kappaB and AP-1, enhanced IL-8- and uPA-secretion, and a further increased invasiveness
Matsumoto et al., FEBS J 2007 (MAP Kinase Signaling System) : Caspase-8- and JNK dependent AP-1 activation is required for Fas ligand induced IL-8 production ... For example, FasL induces nuclear factor kappaB (NF-kappaB) activity and interleukin 8 (IL-8) production by engagement of Fas in human cells ... Here, we found that a dominant negative mutant of c-Jun, a component of the activator protein-1 (AP-1) transcription factor, inhibits FasL induced AP-1 activity and IL-8 production in HEK293 cells ... Unexpectedly, an inhibitor for JNK but not for MAPK/ERK kinase inhibited the FasL induced AP-1 activation and IL-8 production ... These results demonstrate that FasL induced AP-1 activation is required for optimal IL-8 production, and this process is mediated by FADD, caspase-8, and JNK