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FASLG — IL8
Text-mined interactions from Literome
Selam et al., J Clin Endocrinol Metab 2002
(Endometriosis) :
Regulation of
fas ligand expression by
IL-8 in human endometrium ... To test our hypothesis, we studied the in vitro
regulation of
FasL expression and apoptosis by
IL-8 in endometrial cells
Duan et al., Clin Cancer Res 2004
(Osteosarcoma) :
The purpose of these studies was to determine whether alkylating agents affect the expression of
Fas ligand (FasL) and whether
interleukin 12
enhances the sensitivity of human OS cells to alkylating agents
Kreuz et al., J Cell Biol 2004
:
Moreover, down-regulation of both endogenous FLIP isoforms or of endogenous FLIPL alone was sufficient to enhance
FasL induced expression of the NFkappaB target gene
IL8
Imamura et al., J Biol Chem 2004
(Inflammation) :
Fas ligand induces cell-autonomous NF-kappaB activation and
interleukin-8 production by a mechanism distinct from that of tumor necrosis factor-alpha ... Here we found that
FasL induces production of the inflammatory chemokine
IL-8 without inducing apoptosis in HEK293 cells ... These results show that
FasL induces NF-kappaB activation and
IL-8 production by a novel mechanism, distinct from that of TNF-alpha
Trauzold et al., FASEB J 2005
(Adenocarcinoma...) :
Stimulation of TRAF2 overexpressing cells with
CD95 ligand led to induction of NF-kappaB and AP-1, enhanced
IL-8- and uPA-secretion, and a further increased invasiveness
Matsumoto et al., FEBS J 2007
(MAP Kinase Signaling System) :
Caspase-8- and JNK dependent AP-1 activation is required for
Fas ligand induced
IL-8 production ... For example,
FasL induces nuclear factor kappaB (NF-kappaB) activity and
interleukin 8 (IL-8) production by engagement of Fas in human cells ... Here, we found that a dominant negative mutant of c-Jun, a component of the activator protein-1 (AP-1) transcription factor, inhibits
FasL induced AP-1 activity and
IL-8 production in HEK293 cells ... Unexpectedly, an inhibitor for JNK but not for MAPK/ERK kinase inhibited the
FasL induced AP-1 activation and
IL-8 production ... These results demonstrate that
FasL induced AP-1 activation is
required for optimal
IL-8 production, and this process is mediated by FADD, caspase-8, and JNK