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ILK — RAC3

Text-mined interactions from Literome

Zhang et al., J Biol Chem 2004 : Loss of PINCH-1 or ILK , to which alpha- and beta-parvin bind, significantly reduced the activation of Rac , a key signaling event that controls lamellipodium formation and cell spreading
Filipenko et al., Oncogene 2005 : In the present study, we demonstrate that integrin linked kinase (ILK) , which is a focal adhesion protein activated by both ECM and growth factors, is required for the activation of Rac and Cdc42 in epithelial cells ... Taken together, these data demonstrate an essential role of ILK kinase activity in Rac- and Cdc42 mediated actin cytoskeleton reorganization in epithelial cells, further solidifying a role for ILK in the regulation of cancer cell motility and invasiveness