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IRAK3 — TLR8
Text-mined interactions from Literome
Kobayashi et al., Cell 2002
(Salmonella Infections) :
Thus,
IRAK-M regulates
TLR signaling and innate immune homeostasis ... Thus,
IRAK-M regulates
TLR signaling and innate immune homeostasis
Hazeki et al., Eur J Immunol 2003
:
PP2, an inhibitor of Src family tyrosine kinases, prevented the TLR induced phosphorylation of paxillin and Pyk2 without affecting
TLR induced
IRAK activation
Zhang et al., Infect Immun 2005
(Pseudomonas Infections) :
We also determined that MyD88,
IRAK , TRAF6, and Toll interacting protein (Tollip), but not TIRAP, were involved in the
TLR mediated response to P. aeruginosa in HAECs
Pathak et al., J Biol Chem 2005
:
Man-LAM exerts these effects by inducing the expression of
Irak-M , a negative
regulator of
TLR signaling
Seki et al., J Immunol 2010
(Acute Lung Injury...) :
We investigated the role of
IL-1 receptor associated kinase-M ( IRAK-M ), an
inhibitor of MyD88 dependent
TLR signaling, in modulating the innate inflammatory response during influenza pneumonia using a murine model
Turnis et al., J Immunol 2010
:
We found that
IRAK-M is
induced in DCs by
TLR ligation and that its absence from these cells leads to increased activation of the p38-MAPK and NF-?B pathways, which, in turn, improves DC migration to lymph nodes, increases their longevity, and augments their secretion of Th1 skewing cytokines and chemokines
Biswas et al., Eur J Immunol 2011
(Colitis...) :
Interestingly, the expression of
IRAK-M , a negative
regulator of
TLR signaling, is dependent on intestinal commensal flora, as IRAK-M expression was reduced in mice re-derived into a germ-free environment, and introduction of commensal bacteria into germ-free mice induced IRAK-M expression
Wu et al., J Allergy Clin Immunol 2012
(Asthma) :
IL-1 receptor associated kinase M ( IRAK-M ) negatively
regulates TLR signaling
Cole et al., Immunol Lett 2012
:
This study tested if murine bone marrow derived dendritic cells ( BM-DCs ) respond to endotoxin- and bacterial sonicate induced tolerance by decreased inflammatory and increased anti-inflammatory response, and the role of
IRAK-M , an intracellular negative
regulator of
TLR signaling, in this tolerance
Shiu et al., PloS one 2013
(Helicobacter Infections) :
IRAK-M , a negative
regulator of
TLR signaling, was upregulated and we selectedit for investigation of its role in modulating the DC and T cell responses
Sung et al., Biochem Biophys Res Commun 2013
:
Pro B2 markedly elevated the expression of the interleukin (IL)-1 receptor associated kinase (
IRAK)-M protein, a negative
regulator of
TLR signaling