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AKT2 — IRF3

Pathways - manually collected, often from reviews:

• KEGG Influenza A: AKT1/AKT2/AKT3 → IRF3 (protein-protein, activation)

Text-mined interactions from Literome

Lee et al., Biochim Biophys Acta 2008 (Neoplasms...) : In addition, IRF-1 directly inhibited the tube formation of endothelial cells on Matrigel and reduced the expression of p-Akt , and p-eNOS, which play a significant role in angiogenesis when stimulated by VEGF
Zhao et al., Mol Immunol 2010 : We also show that TLR3 induces interferon regulatory factor 3 (IRF3) activation by Akt via an mTOR-p70S6K-4EBP1 pathway
Sugiyama et al., Mol Immunol 2012 : These results suggest that 2-AP inhibits nuclear translocation of phosphorylated-IRF-3 by inhibiting Akt activation