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IFNG — IRF8

Text-mined interactions from Literome

Li et al., J Biol Chem 1999 : Furthermore, transcriptional activation of ICSBP gene by interferon gamma is accompanied by selective nuclear localization of ICSBP in proliferating epithelial cells but not in the nuclei of nondividing cells in the lens fiber compartment
Li et al., Invest Ophthalmol Vis Sci 1999 : Interferon-gamma signaling in human retinal pigment epithelial cells mediated by STAT1, ICSBP , and IRF-1 transcription factors
Kano et al., Biochem Biophys Res Commun 1999 : Taken together, IRF-1 mediates IFN-gamma signaling into primary hepatocytes for cell cycle arrest via p53 expression and for apoptosis
Kantakamalakul et al., J Immunol 1999 : Finally, exogenous expression of ICSBP, found in previous studies to down-regulate MHC I gene expression, failed to repress basal or IFN-gamma induced ICSBP transcription ... These findings extend in a significant way our understanding of the regulation of ICSBP by LPS and IFN-gamma and provide important clues as to its role in macrophage activation
Green et al., Leukemia 1999 (Chromosome Deletion...) : Unexpectedly, all primary acute promyelocytic leukemia ( APL ) samples lacked IRF-1 protein and most exhibited accelerated exon skipping ; furthermore, IRF-1 could not be induced by IFNgamma or all-trans retinoic acid ( ATRA ) which both induce IRF-1 in the NB4 APL cell line
Contursi et al., Proc Natl Acad Sci U S A 2000 : Accordingly, IFNgamma activation of luciferase reporters fused to the GAS element was severely impaired in ICSBP-/- macrophages, but transfection of ICSBP resulted in marked stimulation of these reporters
Wang et al., J Immunol 2000 : Taken together, our results show that ICSBP induced by IFN-gamma/LPS , acts as a principal activator of IL-12p40 transcription in macrophages
Jarosinski et al., J Neuroimmunol 2002 : MHC class I gene promoter activity in astrocytes was controlled entirely through a single enhancer, the MHC-IRF-E , to which IRF-1 bound in response to IFN-gamma in wild type but not in IRF-1 ( -/- ) mouse astrocytes
Tsujimura et al., J Immunol 2002 : ICSBP was expressed in Lin ( - ) progenitor cells, and its levels were markedly increased by IFN-gamma
Kakar et al., J Leukoc Biol 2005 : Interaction of this complex with the HAF1-cis element requires ICSBP tyrosine phosphorylation, which is induced by IFN-gamma stimulation of phagocytic cells
Sheikh et al., Cardiovasc Res 2005 (Arteriosclerosis) : Northern blotting showed that lysoPC transiently and dose-dependently inhibited the IFN gamma induced accumulation of IP-10, Mig and I-Tac but not p48, interferon regulatory factor-1 and guanidine binding protein-1
Xiong et al., J Biol Chem 2005 : IRF-8 induced in peritoneal macrophages by interferon-gamma and lipopolysaccharide was degraded rapidly, and degradation of IRF-8 was blocked by MG132, the proteasome inhibitor, but inhibitors of calpain and lysosomal enzymes had no effect
Shi et al., Int J Biochem Cell Biol 2006 (Breast Neoplasms...) : Both treatments induced USF-1 and IRF binding complexes to promoter IV but only IFNgamma induced the binding of 435-Lung2 nuclear proteins to an ARE-1 site at the promoter III
Bennett et al., Blood 2006 (Inflammation...) : Thus, knock-down of RAX expression by 80 % using small interfering RNA ( siRNA ) prevents IFNgamma/tumor necrosis factor alpha (TNFalpha) induced PKR activation and eIF2alpha phosphorylation, IkappaB degradation, IRF-1 expression, and STAT1 phosphorylation, resulting in enhanced murine embryonic fibroblast (MEF) cell survival
Politis et al., J Immunol 1992 : In this study, the regulation of ICSBP mRNA induction by IFN-gamma was characterized in murine thioglycolate elicited peritoneal macrophages
Buckley et al., Mol Cancer Res 2007 : Using an Affymetrix U95A microarray, IRF-7 was identified as a BRCA1 transcriptional target and was also shown to be synergistically up-regulated by BRCA1 specifically in the presence of IFN-gamma , coincident with the synergistic induction of apoptosis
Schedel et al., Am J Respir Crit Care Med 2008 (Genetic Predisposition to Disease...) : Our results suggest that functionally relevant IRF-1 polymorphisms influence atopy risk, potentially by altering transcription factor binding, IRF-1 gene expression, and IFN-gamma regulation
McGough et al., Mol Cancer Res 2008 (Colonic Neoplasms) : Silencing methyl-CpG binding domain protein 1 ( MBD1 ) expression resulted in IRF8 activation by IFN-gamma in human colon carcinoma cells with methylated IRF8 promoter ... Our data thus suggest that human colon carcinoma cells silence IFN-gamma activated IRF8 expression through MBD1 dependent and PIAS1 mediated inhibition of pSTAT1 function at the methylated IRF8 promoter
Shultz et al., J Interferon Cytokine Res 2009 : Roles of IKK-beta, IRF1 , and p65 in the activation of chemokine genes by interferon-gamma
Yamashita et al., Cancer Sci 2010 (Stomach Neoplasms) : Interferon-gamma induced expression of IRF8 was also enhanced by DAC
Weisz et al., Int Immunol 1994 : ICSBP is expressed constitutively in hematopoietic cells and its expression is further induced by IFN-gamma
Politis et al., J Immunol 1994 : The regulation of ICSBP induction by IFN-gamma was consistent with the characteristics found at the mRNA level ; inhibition by IFN-alpha or glucocorticoids and the requirement for protein kinase C ( as determined pharmacologically ) ... The time course of IFN-gamma induced ICSBP showed an induction of protein that required approximately 12 h to reach maximal levels
Sharf et al., J Biol Chem 1997 : Tyr phosphorylated ICSBP and IRF-2 are detected in expressing cells constitutively, and Tyr phosphorylated IRF-1 is induced by IFN-gamma
Faure et al., J Biol Chem 1999 : The decrease of LPS/IFN-gamma induced IRF-1 promoter activity, IRF-1 synthesis, and IRF-1 activation, by PDTC, genistein, PD98059, and SB 203580, could explained in part the inhibition of the NOS-2 induction by these compounds