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EPO — JAK1

Text-mined interactions from Literome

Bittorf et al., Biol Chem 1999 (Leukemia, Erythroblastic, Acute) : In conclusion, SHP1 regulates the transcriptional activity stimulated by the EPO induced JAK/STAT and MAPK pathways and is involved in the signaling machinery responsible for erythroid differentiation and suppression of apoptosis
Miller et al., Blood 2002 : Red cell development depends on the binding of erythropoietin (EPO) to receptors expressed by erythroid colony forming units ( CFUe ) and the subsequent activation of receptor bound Janus kinase ( Jak2 )
Lai et al., Oncogene 2005 (Carcinoma, Squamous Cell...) : Erythropoietin mediated activation of JAK-STAT signaling contributes to cellular invasion in head and neck squamous cell carcinoma
Kim et al., J Cell Biochem 2012 : Recently, we demonstrated that Epo activates JAK/STAT signaling in hematopoietic stem cells ( HSCs ), leading to the production of bone morphogenetic protein 2 (BMP2) and bone formation and that Epo also directly activates mesenchymal cells to form osteoblasts in vitro
Cokic et al., Journal of translational medicine 2012 : The goal of this study was to observe the function of EPO activation of JAK-STAT and PI3K/AKT pathways in the development of erythroid progenitors from hematopoietic CD34+ progenitor cells, as well as to distinguish early EPO target genes in human erythroid progenitors during ontogeny