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CCND1 — JAK2
Text-mined interactions from Literome
Sakamoto et al., Mol Endocrinol 2007
:
The
Janus kinase 2 is
required for expression and nuclear accumulation of
cyclin D1 in proliferating mammary epithelial cells
Sakamoto et al., Cancer Res 2009
(Cell Transformation, Neoplastic...) :
We have recently reported that
Jak2 controls the expression and nuclear accumulation of
cyclin D1 ... The constitutive activation of ErbB2 signaling, which is an initial event in the formation of mammary cancer, was able to override the functional
role of
Jak2 in regulating the expression of Akt1 and
cyclin D1
Guo et al., PloS one 2011
:
Mechanistic characterization revealed that NSC-743380 suppressed the phosphorylation of C-terminal domain of RNA polymerase II, induced JNK activation,
inhibited JAK2/STAT3 phosphorylation and suppressed
cyclin D1 expression in sensitive human cancer cells
Li et al., PloS one 2012
:
Pharmacological inhibition of
JAK/STAT3 , PI3K/Akt or MEK/ERK signaling by AG490, Wortmannin or U0126, respectively,
reduced leptin induced
cyclin D1 expression and NP cell proliferation