Gene interactions and pathways from curated databases and text-mining

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CCND1 — JAK2

Text-mined interactions from Literome

Sakamoto et al., Mol Endocrinol 2007 : The Janus kinase 2 is required for expression and nuclear accumulation of cyclin D1 in proliferating mammary epithelial cells
Sakamoto et al., Cancer Res 2009 (Cell Transformation, Neoplastic...) : We have recently reported that Jak2 controls the expression and nuclear accumulation of cyclin D1 ... The constitutive activation of ErbB2 signaling, which is an initial event in the formation of mammary cancer, was able to override the functional role of Jak2 in regulating the expression of Akt1 and cyclin D1
Guo et al., PloS one 2011 : Mechanistic characterization revealed that NSC-743380 suppressed the phosphorylation of C-terminal domain of RNA polymerase II, induced JNK activation, inhibited JAK2/STAT3 phosphorylation and suppressed cyclin D1 expression in sensitive human cancer cells
Li et al., PloS one 2012 : Pharmacological inhibition of JAK/STAT3 , PI3K/Akt or MEK/ERK signaling by AG490, Wortmannin or U0126, respectively, reduced leptin induced cyclin D1 expression and NP cell proliferation