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JUN — PTEN

Pathways - manually collected, often from reviews:

• NCI Pathway Database AP-1 transcription factor network: JUN/JUN-FOS complex (JUN-FOS_JUN) → PTEN (PTEN) (transcription, inhibits) Hettinger et al., Cell Death Differ 2007*
  Evidence: reporter gene, physical interaction

Text-mined interactions from Literome

Wang et al., Cancer Res 2005 (MAP Kinase Signaling System) : In addition, overexpression of wild-type PTEN resulted in inhibition of UV-induced AP-1 activity
Koul et al., Mol Cell Biochem 2007 (Glioma) : PTEN down regulates AP-1 and targets c-fos in human glioma cells via PI3-kinase/Akt pathway ... In contrast to its effect on c-fos, PTEN did not affect the expression of c-Jun and other fos family members
Wang et al., Cancer Res 2007 : Regulation of PTEN expression in intestinal epithelial cells by c-Jun NH2-terminal kinase activation and nuclear factor-kappaB inhibition
Goel et al., Cancer Discov 2012 (Prostatic Neoplasms) : We show that the VEGF receptor neuropilin-2 (NRP2) is associated with high-grade, PTEN-null prostate cancer and that its expression in tumor cells is induced by PTEN loss as a consequence of c-Jun activation