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CDK4 — JUND

Text-mined interactions from Literome

Xiao et al., Biochem J 2007 : Induced JunD in intestinal epithelial cells represses CDK4 transcription through its proximal promoter region following polyamine depletion ... In the present study, we show that induced JunD in IECs ( intestinal epithelial cells ) is a transcriptional repressor of the CDK4 gene following polyamine depletion ... Gel shift and chromatin immunoprecipitation assays revealed that JunD bound to the proximal region of the CDK4-promoter in vitro as well as in vivo, while experiments using different CDK4-promoter mutants showed that transcriptional repression of CDK4 by JunD was mediated through an AP-1 binding site within this proximal sequence of the CDK4-promoter ... These results indicate that induced JunD in IECs represses CDK4 transcription through its proximal promoter region following polyamine depletion
Xiao et al., Am J Physiol Cell Physiol 2010 : ATF-2 silencing not only prevented inhibition of CDK4 transcription in polyamine-deficient cells but also abolished repression of CDK4 expression induced by ectopic JunD overexpression