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KITLG — PRL

Text-mined interactions from Literome

Welte et al., Mol Endocrinol 1994 : The effect of PRL on MGF did not require costimulation of cells with the other lactogenic hormones, insulin, and glucocorticoids ... In cell cultures, PRL induced activation of MGF as well as up-regulation of beta-casein gene transcription was confined to confluent cultures of mammary epithelial cells and inhibited by long term incubation of cells with epidermal growth factor
Tourkine et al., J Biol Chem 1995 : We demonstrate that MGF is rapidly activated by PRL alone or by human growth hormone, a natural ligand of many PRL receptors (PRL-Rs), in the cytoplasm and accumulated in the nucleus ... The MGF activation by PRL occurred in the absence of endogenous extracellular matrix, a condition where casein synthesis is known to be markedly reduced
Marte et al., Cell Growth Differ 1994 : Inhibition or down-regulation of PKC reduced the activation of MGF by prolactin as well