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FGF23 — KLB

Pathways - manually collected, often from reviews:

• Reactome Reaction: FGF23 → KLB (reaction) Carpenter et al., Exp Cell Res 1999, Wong et al., Proc Natl Acad Sci U S A 2002, Lax et al., Mol Cell 2002, Fong et al., J Biol Chem 2003, Agazie et al., Oncogene 2003, Ahmed et al., Biochem J 2008, Schüller et al., Biochem J 2008, Klint et al., J Biol Chem 1995, Wang et al., Mol Cell Biol 1994, Ong et al., Biochem Biophys Res Commun 1996, Kanai et al., J Biol Chem 1997, Kouhara et al., Cell 1997, Ong et al., Biochem Biophys Res Commun 1997, Hadari et al., Mol Cell Biol 1998

Text-mined interactions from Literome

Kurosu et al., J Biol Chem 2007 : We demonstrated that Klotho and betaKlotho , homologous single-pass transmembrane proteins that bind to FGFRs, are required for metabolic activity of FGF23 and FGF21, respectively
Wu et al., J Biol Chem 2008 : Both FGF23 and FGF21 require intact alpha or betaKlotho for signaling, respectively, whereas FGF19 can signal through a Klotho chimera consisting of the N terminus of alphaKlotho and the C terminus of betaKlotho
Wu et al., Proc Natl Acad Sci U S A 2009 (Obesity) : Further, FGF19 activated FGFR4 signaling in the presence or absence of betaKlotho , but activation of FGFRs 1c, 2c, or 3c was completely betaKlotho dependent