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CDKN1A — KLF2
Text-mined interactions from Literome
Zhang et al., J Biol Chem 2000
:
The gut enriched
Kruppel-like factor ( Kruppel-like factor 4 )
mediates the transactivating effect of p53 on the
p21WAF1/Cip1 promoter
Wu et al., Oncogene 2004
:
In addition,
KLF2 upregulates
p21WAF1/CIP1 expression ... Additionally, we found that
KLF2 upregulates
p21WAF1/CIP1 promoter activity in Jurkat, HepG2 and SW480 cells ... Finally, we determined that the Sp1-3 binding site is the functional responsive element of KLF2 in the p21WAF1/CIP1 promoter, and we conclude that
KLF2 directly
regulates p21WAF1/CIP1 expression
Song et al., Biochem Biophys Res Commun 2012
(Papilloma) :
Furthermore,
KLF10 dose-dependently
activated p21 ( WAF1/CIP1 ) transcription, which was independent of p53 and Sp1 binding sites in p21 ( WAF1/CIP1 ) promoter