Gene interactions and pathways from curated databases and text-mining

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IL6 — KLK3

Text-mined interactions from Literome

Lin et al., Clin Cancer Res 2001 (Prostatic Neoplasms) : Bicalutamide, an antiandrogen, abolished the IL-6 effect and IL-6 could not activate the PSA and murine mammary tumor virus reporters in AR-negative DU-145 and PC3 cells
Mazmanian et al., Nature 2008 (Colitis...) : Purified PSA administered to animals is required to suppress pro-inflammatory interleukin-17 production by intestinal immune cells and also inhibits in vitro reactions in cell cultures
Bradley et al., Cancer 2009 (Prostatic Neoplasms) : Secondary endpoints included safety, rate of PSA decline, objective response, overall survival, and effects of vorinostat on serum interleukin-6 (IL-6) levels
Ogata et al., Joint Bone Spine 2012 (Arthritis, Psoriatic) : Like rheumatoid arthritis ( RA ), the increased production of interleukin (IL)-6 suggests a pathogenic role of IL-6 in PsA
Ogata et al., Arthritis 2012 : This suggests that the pathogenic roles of IL-6 in PsA and RA are different ... This paper discusses the role of IL-6 in PsA
Tian et al., World J Gastroenterol 2012 : APS could increase IL-1a, IL-2, IL-6 , and TNF-a expression and decrease IL-10 levels