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CASP2 — KRT18
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Kadyrov et al., Placenta 2001
:
In epithelial cells the
caspase mediated cleavage of
cytokeratin 18 during apoptosis leads to the formation of a specific neo-epitope, recognized by the antibody M30
Yang et al., Int J Cancer 2003
(Colorectal Neoplasms...) :
The apoptosis was characterized by chromatin condensation, transferase mediated dUTP nick end labeling ( TUNEL ) staining, proteolytic cleavage of poly ( ADP-ribose ) polymerase ( PARP ) and
cytokeratin 18 , and
activation of
caspase-3
Ku et al., Hepatology 2003
(Liver Diseases) :
Both Fas- and TNF induced apoptosis in liver tissues are associated with
caspase mediated
K18 degradation and increased keratin phosphorylation on several but not all sites
Steele et al., Clin Cancer Res 2008
(Neoplasms) :
Pharmacodynamic measurements included acetylation of histones extracted from peripheral blood mononuclear cells,
caspase dependent cleavage of
cytokeratin-18 , and interleukin-6 levels ... Stable disease was observed in a total of 18 ( 39 % ) patients, including 15 treated for > or =4 cycles, and this was associated with
caspase dependent cleavage of
cytokeratin-18
Petrov et al., Exp Cell Res 2008
:
However, the absolute majority of MyoFbs are non-apoptotic cells as established with two apoptosis-specific methods, flow cytometry and
caspase dependent cleavage of
cytokeratin 18
Olofsson et al., Cancer Biomark 2009
(Colonic Neoplasms...) :
We here demonstrate that whereas the M30-Apoptosense ELISA assay detects human caspase cleaved
CK18 , the mouse and rat CK18
caspase cleavage products are
detected with low affinity