◀ Back to RAF1
LCK — RAF1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database IL2-mediated signaling events:
RAF1 (RAF1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1)
(modification, activates)
Blanchard et al., Oncogene 2000, Lundin Brockdorff et al., Cytokine 2002, Karnitz et al., Mol Cell Biol 1995
Evidence: mutant phenotype, other species
-
NCI Pathway Database SHP2 signaling:
RAF1 (RAF1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1)
(modification, activates)
Blanchard et al., Oncogene 2000, Lundin Brockdorff et al., Cytokine 2002, Karnitz et al., Mol Cell Biol 1995
Evidence: mutant phenotype
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Häfner et al., Mol Cell Biol 1994
(Cell Transformation, Neoplastic) :
Phosphorylation by PKA interferes with the
activation of
Raf-1 by either PKC alpha or the tyrosine kinase
Lck and even can downregulate the kinase activity of Raf-1 previously activated by PKC alpha or amino-terminal truncation
Popik et al., Mol Cell Biol 1996
:
In addition, a catalytically active
Lck was
required for the association of Lck and
Raf-1
Pathan et al., J Biol Chem 1996
:
Activation of T cell
Raf-1 at mitosis
requires the protein-tyrosine kinase
Lck ... We conclude that
Raf-1 is activated during mitosis in T cells and that this mitotic activation of Raf-1 is
dependent on the presence of
Lck