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LIF — LIFR

Pathways - manually collected, often from reviews:

• KEGG Cytokine-cytokine receptor interaction: LIF → Complex of IL6ST-LIFR (protein-protein, activation)
• WikiPathways ESC Pluripotency Pathways: LIF → JAK1/IL6ST/LIFR/JAK1 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: LIF — LIFR (direct interaction, pull down) Bitard et al., J Biol Chem 2003*
• MIPS CORUM LIFR-LIF-gp130 complex: LIFR-LIF-gp130 complex complex (IL6ST-LIF-LIFR) Stahl et al., J Biol Chem 1993*
• IRef Corum Interaction: Complex of LIF-IL6ST-LIFR (association, cross-linking study) Stahl et al., J Biol Chem 1993*
• IRef Dip Interaction: LIF — LIFR (physical association, coimmunoprecipitation) Mosley et al., J Biol Chem 1996*
• IRef Dip Interaction: LIF — LIFR (physical association, affinity chromatography technology) Hudson et al., J Biol Chem 1996*
• IRef Dip Interaction: LIF — LIFR (physical association, biochemical) Zhang et al., J Biol Chem 1998*
• IRef Hprd Interaction: LIFR — LIF (in vitro) Bitard et al., J Biol Chem 2003*, He et al., FEBS Lett 2005*
• IRef Hprd Interaction: Complex of LIFR-IL6ST-LIF-IL6ST-LIFR-LIF-LIF-IL6ST-LIFR (in vivo) He et al., FEBS Lett 2005*
• IRef Intact Interaction: LIF — LIFR (direct interaction, pull down) He et al., FEBS Lett 2005*
• IRef Ophid Interaction: LIF — LIFR (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: LIF — LIFR (aggregation, confirmational text mining) Bitard et al., J Biol Chem 2003*

Text-mined interactions from Literome

World et al., Ann N Y Acad Sci 2001 : However, in the presence of an intact endothelium, LIFR-alpha was upregulated in response to LIF , and accordingly the downstream induction of iNOS expression was also increased
Ding et al., Reproduction 2008 : We also observed that, while the uterine Lif was induced by estrogen, Lif-r and gp130 were induced by progesterone in ovariectomized hamsters
Grossberg et al., Endocrinology 2010 (Anorexia) : We show that arcuate POMC neurons express the LIF-R , and that LIF stimulates the release of the anorexigenic peptide, alpha-MSH from ex vivo hypothalami
Mosley et al., J Biol Chem 1996 (Carcinoma, Hepatocellular) : Our results demonstrate that both LIF and OSM cause tyrosine phosphorylation and activation of the gp130.LIFR combination, but the gp130.OSMRbeta complex is activated by OSM only
Vernallis et al., J Biol Chem 1997 : The leukemia inhibitory factor receptor ( LIF-R ) is activated not only by LIF , but also by cardiotrophin-1, ciliary neurotrophic factor with its receptor, and oncostatin M (OSM)