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LIG1 — PCNA

Pathways - manually collected, often from reviews:

• Reactome Reaction: LIG1 → PCNA (reaction)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: PCNA — LIG1 Ohta et al., J Biol Chem 2002, Montecucco et al., EMBO J 1998*
• IRef Bind_translation Interaction: PCNA — LIG1 (affinity chromatography technology) Ohta et al., J Biol Chem 2002, Montecucco et al., EMBO J 1998*
• IRef Bind_translation Interaction: PCNA — LIG1 (competition binding) Ohta et al., J Biol Chem 2002, Montecucco et al., EMBO J 1998*
• IRef Bind_translation Interaction: PCNA — LIG1 (affinity chromatography technology) Ohta et al., J Biol Chem 2002
• IRef Biogrid Interaction: PCNA — LIG1 (direct interaction, pull down) Montecucco et al., EMBO J 1998*
• IRef Biogrid Interaction: PCNA — LIG1 (physical association, affinity chromatography technology) Ohta et al., J Biol Chem 2002
• MIPS CORUM DNA synthesome complex (15 subunits): DNA synthesome complex (15 subunits) complex (LIG1-PCNA-POLA1-POLA2-POLD1-POLD2-POLD3-POLD4-POLE-POLE2-POLE3-POLE4-PRIM1-PRIM2-RFC1) Coll et al., Oncol Res 1997
• IRef Corum Interaction: Complex of 46 proteins (association, anti bait coimmunoprecipitation) Coll et al., Oncol Res 1997
• IRef Hprd Interaction: PCNA — LIG1 (in vitro) Matsumoto et al., J Biol Chem 1999, Ohta et al., J Biol Chem 2002
• IRef Ophid Interaction: PCNA — LIG1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Tom et al., J Biol Chem 2001 : These results show that PCNA is responsible for the stable association of DNA ligase I to nicked duplex DNA
Song et al., J Biol Chem 2007 : The participation of DNA ligase I in these transactions is directed by physical and functional interactions with proliferating cell nuclear antigen , a DNA sliding clamp, and, replication factor C ( RFC ), the clamp loader