Sharp et al., Proc Natl Acad Sci U S A 2004
(Carcinoma, Non-Small-Cell Lung...) :
LIM domains containing protein 1 (LIMD1) , a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription
Foxler et al., FEBS Lett 2011
:
Mechanistically, LIMD1 interacts with pRB, repressing E2F-driven transcription as well as being a critical component of microRNA mediated gene silencing ... Mechanistically, LIMD1 interacts with pRB, repressing E2F-driven transcription as well as being a critical component of microRNA mediated gene silencing