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LOX — SMAD3
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Atsawasuwan et al., J Biol Chem 2008
:
Furthermore,
LOX suppressed TGF-beta1 induced
Smad3 phosphorylation likely through its amine oxidase activity
Voloshenyuk et al., Cytokine 2011
(MAP Kinase Signaling System) :
Induction of cardiac fibroblast
lysyl oxidase by TGF-ß1
requires PI3K/Akt,
Smad3 , and MAPK signaling ... The increase of
LOX protein in response to TGF-ß1 was
prevented by inhibitors of PI3K,
Smad3 , p38-MAPK, JNK and ERK1/2
Guadall et al., Front Biosci (Elite Ed) 2011
:
Thus, our data support a
role of
Smad signaling and ROS in the up-regulation of
LOX by hypoxia in endothelial cells