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LTA — MMP9

Text-mined interactions from Literome

Hashizume et al., J Reprod Dev 2003 : Both TNF-alpha and TNF-beta strongly stimulated the production of MMP-2 and MMP-9 , whereas IGFs had no effect
Hsieh et al., Neurotox Res 2010 : However, the molecular mechanisms underlying LTA induced MMP-9 expression in rat brain astrocytes ( RBA-1 cells ) remain poorly defined ... Here, the data with zymographic, Western blotting, RT-PCR, and immunofluorescent staining analyses showed that LTA induced MMP-9 expression and activation via a TLR2 activated c-Src dependent transactivation of PDGFR pathway ... Eventually, upregulation of MMP-9 by LTA enhanced cell migration of astrocytes ... Taken together, these results suggested that in RBA-1 cells, activation of NF-kappaB by a c-Src dependent PI3K/Akt-p42/p44 MAPK activation mediated through transactivation of PDGFR is essential for MMP-9 gene upregulation induced by LTA
Hsieh et al., Journal of neuroinflammation 2012 : However, the molecular mechanisms underlying LTA induced redox signal and MMP-9 expression in brain astrocytes remain unclear ... Herein we explored whether LTA induced MMP-9 expression was mediated through redox signals in rat brain astrocytes ( RBA-1 cells ) ... Upregulation of MMP-9 by LTA was evaluated by zymographic and RT-PCR analyses ... These results showed that LTA induced MMP-9 expression via a PKC ( a ) -dependent pathway ... Functionally, LTA induced MMP-9 expression enhanced astrocytic migration
Park et al., Int Immunopharmacol 2013 : In microglia, schizandrin C significantly inhibited lipoteichoic acid (LTA) stimulated pro-inflammatory cytokines and chemokines, prostaglandin E2 ( PGE2 ), nitric oxide ( NO ), and reactive oxygen species ( ROS ) production, and inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and matrix metallopeptidase-9 (MMP-9) protein expressions