◀ Back to PPARA

LTB — PPARA

Text-mined interactions from Literome

Fiedler et al., J Pharmacol Exp Ther 2001 : These results do not support the hypothesis that a pathway of negative feedback regulation of LTB4 metabolism involving PPARalpha exists in hepatocytes, because activation of PPARalpha by LTB4 or other PPARalpha agonists did not correlate with an increase in LTB4 metabolism
Narala et al., J Biol Chem 2010 : Activation of PPAR-alpha reduces secretion of LTB ( 4 ) by stimulating degradation of this fatty acid derivative ... We also show that the LTB ( 4 ) precursors leukotriene A ( 4 ) ( LTA ( 4 ) ) and 5-hydroperoxyeicosatetrenoic acid ( 5-HPETE ) activate PPAR-alpha but have no significant endogenous effect independent of conversion to LTB ( 4 ) ... We conclude that LTB ( 4 ) is a physiologically relevant PPAR-alpha activator in cells of the immune system