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LTA — MAPK13

Text-mined interactions from Literome

Lee et al., Am J Physiol Lung Cell Mol Physiol 2004 : LTA stimulated phosphorylation of p42/p44 MAPK via a Toll-like receptor 2 (TLR2) ... LTA stimulated phosphorylation of p42/p44 MAPK was attenuated by inhibitors of tyrosine kinase ( genistein ), phosphatidylcholine-phospholipase C ( PLC ; D609 ), phosphatidylinositol ( PI ) -PLC ( U-73122 ), PKC ( staurosporine, Gö-6976, rottlerin, or Ro-318220 ), MEK1/2 ( U-0126 ), PI 3-kinase ( LY-294002 and wortmannin ), and an intracellular Ca ( 2+ ) chelator ( BAPTA-AM ) ... These results suggest that in HTSMCs, LTA stimulated p42/p44 MAPK phosphorylation is mediated through a TLR2 receptor and involves tyrosine kinase, PLC, PKC, Ca ( 2+ ), MEK, and PI 3-kinase
Kao et al., Immunology 2005 : The LTA induced p38 MAPK activation was inhibited by genistein, tyrphostin AG126, wortmannin, LY 294002, and SB 203580
Chang et al., Cell Signal 2006 (MAP Kinase Signaling System) : Stimulation of RAW 264.7 macrophages with LTA , PGE2, and dibutyryl-cAMP all caused p38 MAPK activation in a time dependent manner ... LTA mediated p38 MAPK activation was inhibited by indomethacin, NS-398, and SB 203580, but not by PD 98059
Yang et al., Mol Immunol 2009 (MAP Kinase Signaling System) : Those inhibitory effects might be associated with LT interference of LTA signaling pathways mediated through mitogen activated protein kinases ( MAPKs ) since LT suppressed phosphorylation of MAPK , which was induced by LTA
Park et al., Int Immunopharmacol 2013 : Moreover, schizandrin C suppressed LTA induced nuclear factor-kappa B ( NF-?B ), activator protein-1 (AP-1), janus-kinase/signal transducer and activator of transcription ( JAK-STATs ), and mitogen activated protein kinase ( MAPK ) activation