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MED4 — PAK1

Text-mined interactions from Literome

Messerli et al., Phytother Res 2009 (Neoplasms, Experimental...) : Artepillin C (ARC) in Brazilian green propolis selectively blocks oncogenic PAK1 signaling and suppresses the growth of NF tumors in mice ... Also it was demonstrated that ARC suppresses angiogenesis, suggesting the possibility that ARC also blocks oncogenic PAK1 signaling ... Here it is shown for the first time that both ARC and green propolis extract ( GPE ) indeed block the PAK1 signaling selectively, without affecting another kinase known as AKT
Crespin et al., Blood Coagul Fibrinolysis 2009 : Inhibition of Cdc42 and Rac1 by toxin B from Clostridium difficile, that suppresses PAK1/2 activation induced by TRAP and collagen or by A23187 in the presence of calpeptin, decreases polymerization of actin, lamellipodia and filopodia formation and interferes with the shedding of microvesicles