◀ Back to NOTCH2

MFNG — NOTCH2

Pathways - manually collected, often from reviews:

• KEGG Notch signaling pathway: LFNG/MFNG/RFNG → NOTCH1/NOTCH2/NOTCH3/NOTCH4 (protein-protein, activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: NOTCH2 — MFNG (in vivo) Shimizu et al., J Biol Chem 2001*
• IRef Hprd Interaction: NOTCH2 — MFNG (in vitro) Shimizu et al., J Biol Chem 2001*
• IRef Ophid Interaction: NOTCH2 — MFNG (aggregation, confirmational text mining) Shimizu et al., J Biol Chem 2001*
• IRef Ophid Interaction: NOTCH2 — MFNG (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Tan et al., Immunity 2009 : We show that Lunatic Fringe (Lfng) and Manic Fringe (Mfng) cooperatively enhanced the DL1-Notch2 interaction to promote MZ B cell development
Hou et al., J Biol Chem 2012 : In mutant Chinese hamster ovary ( CHO ) cells that do not add galactose (Gal) to the GlcNAc transferred by Fringe, JAG1 induced NOTCH signaling is not inhibited by LFNG or MFNG ... By contrast, MFNG promoted DLL1 induced NOTCH signaling better in the absence of Gal than in its presence ... Gal enhances the effect of LFNG but inhibits the effect of MFNG on DLL1 induced NOTCH signaling, with functional consequences for regulating the strength of NOTCH signaling
Gu et al., PloS one 2012 (Asthma...) : Notch signaling was more activated in asthmatic naïve CD4 ( + ) T cells than in control cells, and Lfng, but not Mfng or Rfng, partly inhibited Notch signaling in asthmatic naïve CD4 ( + ) T lymphocytes