Gene interactions and pathways from curated databases and text-mining

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MMP10 — SP1

Text-mined interactions from Literome

Mudduluru et al., Biosci Rep 2008 (Colorectal Neoplasms) : In Drosophila Schneider SL2-cells , exogenous expression of Sp1/Sp3 increased Axl promoter activity
Jutooru et al., Mol Pharmacol 2010 (Pancreatic Neoplasms) : CDDO-Me also induced reactive oxygen species ( ROS ) and decreased mitochondrial membrane potential ( MMP ) in Panc1 and L3.6pL cells, and cotreatment with antioxidants ( glutathione and dithiothreitol ) blocked the formation of ROS, reversed the loss of MMP , and inhibited down-regulation of Sp1 , Sp3, and Sp4