Gene interactions and pathways from curated databases and text-mining

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CD40LG — MMP25

Text-mined interactions from Literome

Gotoh et al., J Rheumatol 2004 (Arthritis, Rheumatoid...) : CD40-CD154 interaction augments the expression of inflammatory cytokines and MMP in chondrocytes and contributes to an intrinsic process of cartilage degradation in RA
Rahman et al., Inflamm Res 2012 (Disease Models, Animal...) : The MMP inhibitor reduced sepsis induced release of CD40L and maintained normal levels of CD40L on platelets
Wassenaar et al., Clin Exp Immunol 1999 : Therefore, we analysed the CD40L induced MMP production by these fibroblasts in the presence of cytokines that are increased in periodontal lesions, such as IL-1beta, tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma)