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IRF6 — MMP25

Text-mined interactions from Literome

Corbel et al., Pulm Pharmacol Ther 1999 (Inflammation...) : Nedocromil sodium ( 30 mg/kg, ip ) had no influence on the LPS induced MMP activities, on neutrophil recruitment, or on IL-10 level, but this drug elicited a significant inhibition of TNF- alpha level
Fenton et al., Osteoarthritis Cartilage 2000 (Horse Diseases...) : The addition of 25 mg/ml of glucosamine prevented the increase in nitric oxide production, proteoglycan release and MMP activity induced by LPS or rhIL-1
Corbel et al., Eur J Pharmacol 2001 (Acute Disease...) : These findings demonstrate that the two drugs can inhibit the in vivo increase in MMP induced by LPS , batimastat with a direct inhibitor effect on MMP activity and pirfenidone as a consequence of its antiinflammatory effect
Corbel et al., J Pharmacol Exp Ther 2002 (Lung Diseases) : In the first model, the lipopolysaccharide (LPS) induced increase in neutrophils, MMP-9 activity, and tumor necrosis factor (TNF)-alpha and TGF-beta release in bronchoalveolar lavage (BAL) was significantly reduced by RP 73-401 pretreatment
Smith et al., Br J Ophthalmol 2004 : IL-1alpha and LPS had no effect on MMP/TIMP production by cultured corneal epithelial cells and keratocytes
Nareika et al., Am J Physiol Endocrinol Metab 2005 : Sodium lactate increases LPS stimulated MMP and cytokine expression in U937 histiocytes by enhancing AP-1 and NF-kappaB transcriptional activities
Robinson et al., Shock 2006 (Endotoxemia) : As LPS induced gastric injury is mediated in part by iNOS, and NO modulates MMP production in vitro, we hypothesized that NOS inhibition would similarly modulate LPS induced gastric MMP production ... Therefore, the purpose of these studies was to compare the effects of selective and nonselective NOS inhibition on LPS induced gastric MMP production
Nareika et al., J Endocrinol 2008 : We have demonstrated recently that high glucose augments lipopolysaccharide (LPS) stimulated matrix metalloproteinase ( MMP ) and cytokine expression by U937 mononuclear cells and human monocyte derived macrophages
Cheng et al., Mol Cell Biochem 2009 : Evidences suggest that lipopolysaccharide (LPS) participates in the inflammatory response in the cardiovascular system ; however, it is unknown if LPS is sufficient to upregulate expressions and/or activity of uPA, tPA, MMP-2 , and MMP-9 in myocardial cells ... In this study, we treated H9c2 cardiomyoblasts with LPS to explore whether LPS upregulates uPA, tPA, MMP-2 , and MMP-9, and further to identify the precise molecular and cellular mechanisms behind this upregulatory responses ... Collectively, these results suggest that LPS upregulates the expression and/or activity of uPA, MMP-2 , and MMP-9 through ERK1/2 signaling pathway in H9c2 cardiomyoblasts
Park et al., J Neuroimmunol 2009 (Encephalitis...) : KRG and GTS inhibited LPS induced expression of iNOS, MMP-9 and proinflammatory cytokines in microglial cells
Ho et al., J Interferon Cytokine Res 2010 : Modulation of FLI-1 expression using either RNA interference or forced expression identified a positive role for FLI-1 in contributing to LPS induced expression of MMP-1, MMP-3 , MMP-10, and interleukin-10 (IL-10)
Hyc et al., Int J Mol Med 2011 : LPS increased the mRNA levels of IL-6, IL-1ß, TGF-ß1, MMP1a, MMP1b, MMP3 , MMP9, MMP13, MMP14, TIMP1 and TIMP3 while the mRNA levels of MMP2, TIMP2 and TIMP4 were significantly decreased
Kraus et al., PloS one 2012 (Bacteroidaceae Infections...) : In cell cultures, LPS induced a significant up-regulation of interleukin (IL) 1ß, IL6, IL8, MMP1 and MMP3
Kuo et al., J Periodontal Res 2012 : In the presence of both CsA and LPS , the MMP activities inhibited by CsA could still be observed in the co-cultures ... In the individual cultures, in contrast, the CsA inhibited MMP activities, in the presence of LPS , were minimally detected ... This study demonstrated that, in co-cultures of human gingival fibroblasts and U937 macrophages, CsA could inhibit MMP activities in the presence of P. gingivalis LPS
McElroy et al., PloS one 2012 : LPS induction of COX-2 requires Src-family kinase signaling while LPS transactivation of EGFR requires matrix metalloprotease ( MMP ) activity
Marquis et al., BMC complementary and alternative medicine 2012 (Periodontal Diseases) : The effects of auraptene and lacinartin on LPS induced cytokine and MMP secretion by macrophages were determined by immunological assays
Ko et al., Arch Oral Biol 2012 : Myricetin suppresses LPS induced MMP expression in human gingival fibroblasts and inhibits osteoclastogenesis by downregulating NFATc1 in RANKL induced RAW 264.7 cells
Bougault et al., Arthritis Rheum 2012 (Disease Models, Animal...) : LPS , IL-1a, and TNFa dose-dependently increased MMP-3, MMP-9 , and MMP-13 activity in cultured chondrocytes and in NLRP3 ( -/- ) chondrocytes, and this effect was not changed by inhibiting caspase 1 or IL-1ß
Lin et al., Shock 2013 (Acute Lung Injury) : In addition, LPS increased pulmonary tissue wet-to-dry weight ratio and tumor necrosis factor a and interleukin 8 levels in plasma and bronchoalveolar lavage fluid enhanced the expression of E-selectin, intercellular adhesion molecule 1, myeloperoxidase, MMP-2 , and MMP-9, whereas it decreased the expression of AQP-1 and AQP-5 in pulmonary tissue, all of which were attenuated by SalB pretreatment
Lew et al., PloS one 2013 (Fibrosis) : LPS increased LV expression of collagen Ia1, collagen IIIa1, MMP2, MMP9 , TIMP1, periostin and IL-6 ( P < 0.05 moderate vs low dose LPS and vs control )
Iwata et al., PloS one 2013 (Intervertebral Disc Displacement...) : Further, lipopolysaccharide (LPS) induced expression of TNF-a, MMP3, MMP13 , VEGF, and PGES mRNA in the 3D cultures, creating a molecular milieu that mimics that of degenerated NP
Lively et al., Journal of neuroinflammation 2013 (Wounds and Injuries) : IL4 increased MMP2 and cathepsins S and K ; whereas LPS increased MMP9, MMP12 , MMP14 ( MT1-MMP ), heparanase, and cathepsin L1
Panagakos et al., J Endod 1996 : Little information is currently known regarding the effects of cytokines and lipopolysaccharides (LPS's) on matrix metalloproteinase ( MMP ) production by pulp cells in vitro
Shankavaram et al., J Leukoc Biol 1998 : These results provide evidence that tyrosine phosphorylation of cPLA2 is one of the initial steps needed for the LPS induced MMP production in human monocytes
Deb et al., J Neurosci Res 1999 (Brain Neoplasms...) : A beta, but not interleukin-1beta (IL-1beta) or lipopolysaccharide (LPS) , stimulated an active form of MMP-2 in human U87 glioblastoma cells, as well as increased the expression of the well-known activator of MMP-2, membrane-type ( MT ) -MMP