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APOB — MTTP

Pathways - manually collected, often from reviews:

• Reactome Reaction: APOB → MTTP (reaction) Gordon et al., Trends Cell Biol 1995*, Wu et al., J Biol Chem 1996*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MTTP — APOB (direct interaction, two hybrid) Bradbury et al., J Biol Chem 1999*
• IRef Hprd Interaction: MTTP — APOB (two hybrid) Liang et al., J Biol Chem 2001*, Bradbury et al., J Biol Chem 1999*
• IRef Hprd Interaction: MTTP — APOB (in vivo) Liang et al., J Biol Chem 2001*, Bradbury et al., J Biol Chem 1999*
• IRef Ophid Interaction: APOB — MTTP (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: APOB — MTTP (aggregation, confirmational text mining) Bradbury et al., J Biol Chem 1999*

Text-mined interactions from Literome

Raabe et al., J Clin Invest 1999 : We conclude that MTP is essential for transferring the bulk of triglycerides into the lumen of the ER for VLDL assembly and is required for the secretion of apo B-100 from the liver
Leung et al., J Biol Chem 2000 : Contrary to our expectations, half-normal levels of MTP reduced the plasma apoB100 levels to the same extent ( approximately 25-35 % ) at each level of apoB synthesis
Bakillah et al., Biochemistry 2000 : Decreased secretion of ApoB follows inhibition of ApoB-MTP binding by a novel antagonist
Borradaile et al., Diabetes 2003 (Carcinoma, Hepatocellular...) : In HepG2 human hepatoma cells, naringenin inhibits apolipoprotein B (apoB) secretion primarily by inhibiting microsomal triglyceride transfer protein and enhances LDL receptor (LDLr) mediated apoB containing lipoprotein uptake
Améen et al., J Biol Chem 2005 : This effect is paralleled by a change in apoB-100 secretion, indicating that the effect of Wy on apoB-100 secretion is mediated by increased expression of MTP
Cuchel et al., N Engl J Med 2007 (Hyperlipoproteinemia Type II) : Inhibition of the microsomal triglyceride transfer protein by BMS-201038 resulted in the reduction of LDL cholesterol levels in patients with homozygous familial hypercholesterolemia, owing to reduced production of apolipoprotein B
Wang et al., J Biol Chem 1996 : We studied the role of microsomal triglyceride transfer protein ( MTP ) in the synthesis, secretion, and cotranslational degradation of apolipoprotein ( apo ) B using nonhepatic COS-7 cells that expressed C-terminally truncated forms of apoB ( from apoB15 to apoB94 ) with or without the large subunit of human MTP
Benoist et al., J Biol Chem 1997 : Co-translational degradation of apolipoprotein B100 by the proteasome is prevented by microsomal triglyceride transfer protein ... During the first 4 min of chase, synthesis of apoB polypeptides the size of 100-200 kDa was insensitive to the inhibitor, suggesting that inhibition of MTP did not affect the initiation of apoB100 translation
Nemeth-Slany et al., Atherosclerosis 1997 : Apo B expression is confined to the intestine and liver, and its secretion from these tissues is dependent on the expression of a lipid transfer protein, microsomal triglyceride transfer protein ( MTP )
Wang et al., J Biol Chem 1997 : Secretion of apolipoprotein B (apoB) from mammalian cells requires the presence of functional microsomal triglyceride transfer protein ( MTP )
van Greevenbroek et al., J Lipid Res 1998 : This study was designed to gain insight into the role of microsomal triglyceride transfer protein ( MTP ) in the association of apolipoprotein ( apo ) B with lipid during intestinal lipoprotein assembly