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CEBPB — MYB
Pathways - manually collected, often from reviews:
-
NCI Pathway Database C-MYB transcription factor network:
Myb (MYB)
→
CEBP (CEBPB)
(transcription, activates)
Mink et al., Biochim Biophys Acta 1999*
Evidence: reporter gene, other species
-
NCI Pathway Database C-MYB transcription factor network:
Myb (MYB)
→
CEBPB (CEBPB)
(transcription, activates)
Mink et al., Biochim Biophys Acta 1999*
Evidence: reporter gene, other species
-
NCI Pathway Database C-MYB transcription factor network:
Myb (MYB)
→
CEBP (CEBPB/CEBPA/CEBPD)
(transcription, activates)
Tahirov et al., Cell 2002, Burk et al., EMBO J 1997*
Evidence: mutant phenotype, reporter gene, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
a-cMyb (MYBL1/MYB)
→
CEBPB (CEBPB)
(transcription, inhibits)
Monticelli et al., Mol Immunol 2002*, Gascan et al., J Exp Med 1991, Delphin et al., J Exp Med 1995, Köhler et al., Eur J Immunol 1993, Takeda et al., Nature 1996, Shimoda et al., Nature 1996, Kaplan et al., Immunity 1996
Evidence: mutant phenotype, reporter gene, physical interaction, other species
-
NCI Pathway Database C-MYB transcription factor network:
BRM/CEBP complex (SMARCA2-CEBPB_CEBPA_CEBPD)
→
PIM1/p100/Myb complex (PIM1-SND1-MYB)
(transcription, activates)
Kowenz-Leutz et al., Mol Cell 1999, Tahirov et al., Cell 2002, Ness et al., Genes Dev 1993, Burk et al., EMBO J 1993, Leverson et al., Mol Cell 1998
Evidence: mutant phenotype, reporter gene, physical interaction, other species
-
NCI Pathway Database C-MYB transcription factor network:
Myb (MYB)
→
CEBP (CEBPB/CEBPA/CEBPD)
(transcription, activates)
Oelgeschläger et al., Mol Cell Biol 1996*
Evidence: mutant phenotype, reporter gene, physical interaction, other species
-
NCI Pathway Database C-MYB transcription factor network:
Myb (MYB)
→
CEBP (CEBPB/CEBPA/CEBPD)
(transcription, activates)
Lutz et al., Blood 2001*
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database C-MYB transcription factor network:
Myb (MYB)
→
BRM/CEBP complex (SMARCA2-CEBPB_CEBPA_CEBPD)
(transcription, activates)
Kowenz-Leutz et al., Mol Cell 1999, Tahirov et al., Cell 2002, Sramko et al., J Biol Chem 2006*, Ness et al., Genes Dev 1993, Burk et al., EMBO J 1993
Evidence: mutant phenotype, reporter gene, physical interaction, other species
-
NCI Pathway Database C-MYB transcription factor network:
Myb (MYB)
→
BRM/CEBP complex (SMARCA2-CEBPB_CEBPA_CEBPD)
(transcription, activates)
Kowenz-Leutz et al., Mol Cell 1999, Bies et al., J Biol Chem 2002*, Tahirov et al., Cell 2002, Ness et al., Genes Dev 1993, Burk et al., EMBO J 1993
Evidence: mutant phenotype, reporter gene, physical interaction, other species
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Mink et al., Biochim Biophys Acta 1999
:
The
v-Myb oncoprotein
activates C/EBPbeta expression by stimulating an autoregulatory loop at the C/EBPbeta promoter ... We show that the
C/EBPbeta promoter is
activated synergistically by
v-Myb and C/EBPbeta and that transcription of the endogenous C/EBPbeta gene is increased by v-Myb ... Taken together, our data suggest a model for the regulation of C/EBPbeta expression in which
v-Myb stimulates the synthesis of
C/EBPbeta by enhancing an autoregulatory loop acting on the C/EBPbeta promoter
Karafiát et al., Blood 2001
:
In agreement with that, the wild-type
v-Myb induces high expression of myeloid factors
C/EBP beta , PU.1, and Egr-1 in its target cells, whereas SCL, GATA-1, and c-Myb are more abundant in cells expressing the v-Myb LZR mutant
Kintscher et al., Oncogene 2004
:
Here we have addressed the mechanism by which
v-Myb affects
C/EBPbeta expression ... Previous work has shown that v-Myb acts on the C/EBPbeta promoter ; it now appears that
Myb stimulates
C/EBPbeta expression by acting on the promoter as well as on an enhancer of the C/EBPbeta gene