Colasanti et al., J Biol Chem 1999
(Astrocytoma) :
Furthermore, LPS plus IFNgamma increased the tyrosine phosphorylation of NOS-I , with a concomitant inhibition of its enzyme activity
Palomba et al., J Biol Chem 2004
:
Previous results have indicated that lipopolysaccharide (LPS) plus interferon-gamma (IFNgamma) inhibits nitric-oxide synthase (NOS)-I activity in glial cells ... Finally, we have demonstrated that the LPS/IFNgamma dependent tyrosine phosphorylation of NOS-I and inhibition of its activity are mediated by endogenous AA
Yang et al., DNA Cell Biol 2008
:
IFN-gamma induced enhancement of NOS-1 activity is crucial for its antiviral activity in the central nervous system ... Overexpression of PIN results in lower constitutive NOS-1 expression and activity, and diminishes activation of NOS-1 by IFN-gamma ... Our findings indicate that in neurons, IFN-gamma upregulates NOS-1 through proteasomal degradation of PIN