Gene interactions and pathways from curated databases and text-mining

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Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Zhong et al., Biochem Biophys Res Commun 2004 : COBRA1 inhibits AP-1 transcriptional activity in transfected cells ... Here, we report that ectopic expression of COBRA1 inhibited activator protein 1 (AP-1) transcriptional activity in transfected cells in a dose dependent manner, whereas reduction of endogenous COBRA1 with a small interfering RNA significantly enhanced AP-1 mediated transcriptional activation
McChesney et al., Cancer Res 2006 (Adenocarcinoma...) : Using several truncated mutants and site mutants of the TFF1 promoter, we have shown that COBRA1 can negatively regulate the activator protein-1 (AP-1) complex at the TFF1 promoter and thus down-regulate TFF1 expression in gastric cancer cell lines