◀ Back to TNF
NFATC2 — TNF
Pathways - manually collected, often from reviews:
-
KEGG Natural killer cell mediated cytotoxicity:
NFAT5/NFATC1/NFATC2/NFATC3/NFATC4
→
TNF
(protein-protein, indirect effect)
-
NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes:
NFAT1-c-4 (dimer)/EGR4 complex (NFATC1_NFATC2_NFATC3-EGR4)
→
TNF-alpha (TNF)
(transcription, activates)
Decker et al., Nucleic Acids Res 2003, McCaffrey et al., J Biol Chem 1994, Goldfeld et al., J Exp Med 1993
Evidence: mutant phenotype, reporter gene, physical interaction, other species
-
NCI Pathway Database Downstream signaling in naïve CD8+ T cells:
NFAT1-c-4 (dimer)/EGR4 complex (NFATC1_NFATC2_NFATC3-EGR4)
→
TNF-alpha (TNF)
(transcription, activates)
Decker et al., Nucleic Acids Res 2003, Barouch-Bentov et al., J Immunol 2005, McCaffrey et al., J Biol Chem 1994, Goldfeld et al., J Exp Med 1993
Evidence: mutant phenotype, reporter gene, physical interaction, other species
Text-mined interactions from Literome
Tsytsykova et al., J Exp Med 2000
(Shock, Septic) :
These results demonstrate that
NFATp is an essential
activator of immediate early
TNF-alpha gene expression in T cells and they present in vivo evidence of the inducer- and cell type-specific regulation of TNF-alpha gene expression
Esensten et al., Nucleic Acids Res 2005
:
NFATp , a member of the nuclear factor of activated T cells ( NFAT ) family of transcription factors,
plays a critical role in
TNF gene regulation under a variety of conditions
Kaminuma et al., J Immunol 2008
:
Ectopic expression of
NFATc2 but not NFATc1, especially its short isoform,
enhanced TNF-alpha synthesis in human T cells at the gene transcription level, whereas both NFATs augmented IL-2 expression
Falvo et al., Proc Natl Acad Sci U S A 2008
:
We also show that these NFATp subdomains interact with the coactivator CBP ( CREB binding protein ), which is required for
NFATp dependent
TNF gene transcription
Via et al., PloS one 2012
(Disease Susceptibility...) :
These results thus demonstrate that NFATp plays a critical role in immune containment of TB disease in vivo, through the
NFATp dependent expression of
TNF and IFN-? in T cells
McCaffrey et al., J Biol Chem 1994
(Cell Transformation, Neoplastic) :
The
role of
NFATp in cyclosporin A-sensitive
tumor necrosis factor-alpha gene transcription ...
NFATp binds to two sites within the kappa 3 element, and occupancy of both sites is
required for
TNF alpha gene induction ... The
involvement of
NFATp in transcriptional activation of both the interleukin-2 and
TNF alpha genes suggests that this factor plays an important role in the coordinate induction of multiple cytokine genes, starting at the earliest stages of T cell activation
Tsai et al., Mol Cell Biol 1996
:
Tumor necrosis factor alpha gene regulation in activated T cells
involves ATF-2/Jun and
NFATp
Tsai et al., Mol Cell Biol 1996
(Lymphoma) :
Cell-type-specific
regulation of the human
tumor necrosis factor alpha gene in B cells and T cells by
NFATp and ATF-2/JUN ... In A20 B cells, the
TNF-alpha gene is not
regulated by
NFATp bound to the kappa 3 element