Gene interactions and pathways from curated databases and text-mining

◀ Back to TNF

NFATC2 — TNF

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Tsytsykova et al., J Exp Med 2000 (Shock, Septic) : These results demonstrate that NFATp is an essential activator of immediate early TNF-alpha gene expression in T cells and they present in vivo evidence of the inducer- and cell type-specific regulation of TNF-alpha gene expression
Esensten et al., Nucleic Acids Res 2005 : NFATp , a member of the nuclear factor of activated T cells ( NFAT ) family of transcription factors, plays a critical role in TNF gene regulation under a variety of conditions
Kaminuma et al., J Immunol 2008 : Ectopic expression of NFATc2 but not NFATc1, especially its short isoform, enhanced TNF-alpha synthesis in human T cells at the gene transcription level, whereas both NFATs augmented IL-2 expression
Falvo et al., Proc Natl Acad Sci U S A 2008 : We also show that these NFATp subdomains interact with the coactivator CBP ( CREB binding protein ), which is required for NFATp dependent TNF gene transcription
Via et al., PloS one 2012 (Disease Susceptibility...) : These results thus demonstrate that NFATp plays a critical role in immune containment of TB disease in vivo, through the NFATp dependent expression of TNF and IFN-? in T cells
McCaffrey et al., J Biol Chem 1994 (Cell Transformation, Neoplastic) : The role of NFATp in cyclosporin A-sensitive tumor necrosis factor-alpha gene transcription ... NFATp binds to two sites within the kappa 3 element, and occupancy of both sites is required for TNF alpha gene induction ... The involvement of NFATp in transcriptional activation of both the interleukin-2 and TNF alpha genes suggests that this factor plays an important role in the coordinate induction of multiple cytokine genes, starting at the earliest stages of T cell activation
Tsai et al., Mol Cell Biol 1996 : Tumor necrosis factor alpha gene regulation in activated T cells involves ATF-2/Jun and NFATp
Tsai et al., Mol Cell Biol 1996 (Lymphoma) : Cell-type-specific regulation of the human tumor necrosis factor alpha gene in B cells and T cells by NFATp and ATF-2/JUN ... In A20 B cells, the TNF-alpha gene is not regulated by NFATp bound to the kappa 3 element