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CD28 — NFKBIA
Text-mined interactions from Literome
Pioli et al., Eur J Immunol 1999
:
Cytotoxic T lymphocyte antigen 4 ( CTLA-4 ) inhibits
CD28 induced
IkappaBalpha degradation and RelA activation
Li et al., J Biol Chem 2005
:
Finally, we found that
TCR/CD28 costimulation
induces IkappaBalpha , IkappaBbeta, and IkappaBepsilon degradation, and PKC is required for IkappaBalpha and IkappaBepsilon but not IkappaBbeta degradation
Lai et al., J Biol Chem 1994
:
CD28 signaling
causes a sustained down-regulation of
I kappa B alpha which can be prevented by the immunosuppressant rapamycin ... We showed that
CD28 signaling, distinct from other stimuli such as phorbol 12-myristate 13-acetate, IL-1, and tumor necrosis factor-alpha,
caused a sustained down-regulation of the inhibitor
I kappa B alpha in Jurkat T cells ... Remarkably, the
CD28 mediated down-regulation of
I kappa B alpha was prevented by rapamycin but not by CsA
Harhaj et al., J Biol Chem 1998
:
Catalytically inactive forms of IKKs are able to block the in vivo phosphorylation of
IkappaB alpha induced by mitogen and
CD28