Gene interactions and pathways from curated databases and text-mining

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MAPK7 — NGF

Text-mined interactions from Literome

Brodie et al., Cell Growth Differ 1999 (Translocation, Genetic) : In cells overexpressing a PKC-epsilon dominant negative mutant, NGF induced reduced neurite outgrowth and a more transient phosphorylation of MAPK than in controls
Zapf-Colby et al., Oncogene 1999 : While pretreatment with mitogen activated protein kinase kinase ( MKK ) inhibitor PD98059 ( 30 microM ) results in 100 % inhibition of IGF-I stimulated MAPK phosphorylation ( IC50 < 1 microM ), NGF mediated MAPK phosphorylation is only decreased by 50 % ( IC50=3 microM ) ... Pretreatment with U73122 ( IC50=7 microM ) results in an 87 % inhibition of NGF mediated MAPK phosphorylation, while cotreatment with PD98059 and U73122 results in 97 % inhibition
Maguire et al., Hippocampus 1999 : The data also indicate that NGF increased phosphorylation of trkA and the mitogen activated protein kinase extracellular signal regulated kinase ( ERK ) in dentate gyrus in vitro
Tagliabue et al., J Biol Chem 2000 (Breast Neoplasms...) : Inhibition of NGF induced MAPK activation by an antibody directed against the extracellular domain of TrkA but not by an inhibitor of TrkA phosphorylation demonstrated the requirement of NGF binding but not of proto-TrkA kinase activity for MAPK activation, suggesting the recruitment of another kinase for transmission of the mitogenic signaling ... Down-modulation of p185 ( HER2 ) expression in a breast carcinoma line transfected with a construct containing an anti-p185 ( HER2 ) antibody sequence and expressing proto-TrkA impaired NGF induced MAPK activation and proliferation
Wooten et al., Mol Cell Biol 2000 : We previously reported that in PC12 cells NGF induced activation of mitogen activated protein kinase ( MAPK ) occurs independently of classical and nonclassical PKC isoforms, whereas aPKC isoforms were shown to be required for NGF induced differentiation ... Inhibitors of PKC-iota activity and PI3K had no effect on NGF induced MAPK or p38 activation but reduced NGF stimulated c-Jun N-terminal kinase activity
Mogi et al., Life Sci 2000 (MAP Kinase Signaling System) : Further, a specific inhibitor of p38 mitogen activated protein kinase ( MAPK ), i.e., SB203580, inhibited the induction of NGF in cytokines treated cells in a dose dependent manner whereas a specific inhibitor of classic MAPK , PD98059 had no effect on the induction of NGF
Zhu et al., Clin Cancer Res 2001 (Pancreatic Neoplasms) : NGF led to the phosphorylation of TrkA, mitogen activated protein kinase ( MAPK ), and p38 MAPK but not stress activated protein kinase/c-Jun NH2-terminal kinase in PANC-1 and MIA-PaCa-2 cells
Lou et al., Mol Biol Cell 2001 : When GIPC is overexpressed in PC12 ( 615 ) cells, NGF induced phosphorylation of mitogen activated protein ( MAP ) kinase ( Erk1/2 ) decreases ; however, there is no effect on phosphorylation of Akt, phospholipase C-gamma1, or Shc
Yasui et al., J Biol Chem 2001 : This differential response has been explained by the duration of mitogen activated protein kinase ( MAPK ) activation ; NGF induces sustained MAPK activation but EGF leads short lived activation
Rakhit et al., Mol Pharmacol 2001 : This was supported by data showing that the NGF dependent activation of p42/p44 MAPK is potentiated in cells transfected with G protein coupled receptor kinase 2 ( GRK2 ) or beta-arrestin I ... Indeed, inhibitors of clathrin mediated endocytosis ( e.g., monodansylcadaverine, concanavalin A, and hyperosmolar sucrose ) reduced the NGF dependent activation of p42/p44 MAPK
Wu et al., J Neurosci 2001 (MAP Kinase Signaling System) : Pretreatment of PC12 cells with brefeldin A ( BFA ), which disrupts the Golgi and endosomal compartments, had little effect on Ras activation but strongly inhibited NGF induced Rap1 activation and continuing MAPK activation ... We propose that endosomes are a site from which NGF induces the prolonged activation of Rap1 and MAPK
Zhu et al., Mol Carcinog 2002 (Disease Progression...) : NGF has the potential to stimulate the growth of some pancreatic cancer cell lines, and this effect is mediated by the phosphorylation of tyrosine kinase receptor A and mitogen activated protein kinase activation ; it is dependent on the expression levels of tyrosine kinase receptor A and p75 receptors
Kutcher et al., Am J Physiol Cell Physiol 2003 (MAP Kinase Signaling System) : NGF triggers a signaling cascade ( MAPK ) that results in the differentiation of PC12 cells into a neuronal phenotype, marked by neurite outgrowth
Ohmichi et al., J Biol Chem 1992 : Similarly, the NGF dependent activation of mitogen activated protein ( MAP ) kinase is detected in 3T3-c-trk cells, but not in untransfected 3T3 or Chinese hamster ovary cells overexpressing p75
Moughal et al., Cell Signal 2004 (MAP Kinase Signaling System) : Third, the over-expression of recombinant LPA ( 1 ) receptor potentiated LPA- and NGF dependent activation of p42/p44 MAPK
Lelkes et al., Neurotox Res 2001 : Culturing PC12 cells in high glucose resulted in alterations in basal and NGF stimulated mitogen activated protein kinase ( MAPK ) signaling pathways, specifically in a switch from the neuronal survival/differentiation associated MAPK ERK to that of apoptosis/stress associated MAPK p38 and JNK
Yamazaki et al., Eur J Pharmacol 2004 : These inhibitory effects of ODQ were similar to those observed for nerve growth factor (NGF) induced neurite outgrowth and MAPK phosphorylation ... These results suggest that the soluble guanylate cyclase-PKG signaling pathway is important for MAPK activation by genipin as well as NGF during neuritogenesis in PC12h cells
Obata et al., Neuroscience 2004 (Pain...) : Therefore, we suggest that after inflammation near the cell body, NGF synthesized within the nerve root and DRG induces BDNF expression through trkA receptors and intracellular ERK-MAPK
Behrsing et al., J Neurosci Res 2004 : At maximal 32P incorporation, MAPK activity in response to ATP, NGF , and NGF + ATP was two-, four-, and sixfold higher, respectively, than control values ; the observed increase was qualitatively confirmed using Western blots
Qiu et al., Dev Growth Differ 2004 : A well documented example for signal specificity determination is found in rat phaeochromocytoma PC12 cells where epidermal growth factor (EGF) stimulation produces a transient mitogen activated protein kinase ( MAPK ) activation and leads to cell proliferation while nerve growth factor (NGF) initiates a sustained MAPK activation and induces cell differentiation
Price et al., Eur J Pharmacol 2005 : FK1706 also potentiated NGF induced MAPK activation, with a similar dose-dependency to that necessary for potentiating neurite outgrowth
Kuwako et al., J Neurosci 2005 (Prader-Willi Syndrome) : NGF induced phosphorylation of TrkA and mitogen activated protein kinase was significantly diminished in the necdin-null sensory ganglia
Pizzio et al., Eur J Neurosci 2005 : NGF activates c-FOS and ERK1/2-MAPK in the suprachiasmatic nuclei, the site of a circadian clock in mammals, when administered during the subjective night but not during the day
Zagozdzon et al., Cell Signal 2006 (MAP Kinase Signaling System) : Down-regulation of the expression of endogenous CHK by RNAi in PC12 cells led to a significant decrease in MAPK activation following NGF stimulation
Puntambekar et al., J Neurochem 2005 : Inhibition of NADPH oxidase activity also attenuated NGF dependent p38 MAPK activation
Park et al., Mol Cells 2006 : The p38 mitogen activated protein kinase ( MAPK ) inhibitor, SB203580, phosphatidylinositol 3-kinase (PI-3K) inhibitor, LY294003, protein kinase A (PKA) inhibitor, H89, and protein kinase C ( PKC ) inhibitor, chelerythrine, had no effect on activation of promoter IV by NGF
Althaus et al., J Neurochem 2006 : Similarly, a cleavage-resistant proNGF ( R-1G ) activated MAPK and promoted oligodendroglial process regeneration
Moughal et al., J Neurochem 2006 : Significantly, Ki16425 also reduced the NGF induced stimulation of p42/p44 MAPK and inhibited NGF stimulated neurite outgrowth ... Thirdly, the over-expression of the C-terminal GRK-2 peptide, which sequesters Gbetagamma subunits, reduced the NGF induced activation of p42/p44 MAPK
Varsano et al., Mol Cell Biol 2006 : GIPC 's interaction with APPL is essential for recruitment of GIPC to peripheral endosomes and for TrkA signaling, because a GIPC PDZ domain mutant that can not bind APPL or APPL knockdown with small interfering RNA inhibits NGF induced GIPC recruitment, mitogen activated protein kinase activation, and neurite outgrowth
Ziegler et al., Ann N Y Acad Sci 2006 : In the present study, we examined the influence of DHEA on nerve growth factor (NGF) mediated survival in serum deprived PC12 cells and analyzed the influence of DHEA on NGF induced ERK1/2 mitogen activated protein ( MAP ) kinase activation by enzyme linked immunosorbent assay ( ELISA )
Williams et al., Neurosci Lett 2007 (MAP Kinase Signaling System...) : Age dependent loss of NGF signaling in the rat basal forebrain is due to disrupted MAPK activation
Peng et al., Toxicology 2007 (Glioma) : It has been reported mitogen activated protein kinase ( MAPK ) mediates NGF synthesis induced by SMase activation
Tucker et al., Cell Signal 2008 : Inhibition of either Src or FAK activity attenuated both laminin and/or NGF induced PI 3-K/Akt and MEK/MAPK signalling pathways, as well as neurite growth
Jiang et al., Mol Immunol 2008 : Furthermore, LPS induced upregulation of NGF and p75 ( NTR ) could be inhibited by p38MAPK inhibitor SB203580 and NF-kappaB inhibitor PDTC, suggesting TLR4 triggered activation of p38MAPK and NF-kappaB pathways are responsible for the process
Nguyen et al., J Biochem Mol Biol 2007 (MAP Kinase Signaling System) : By contrast, Overexpression of WT-PLC-gamma1 exhibited sustained NGF induced MAPK activation, and triggered transient Akt activation resulting in profound inhibition of neurite outgrowth
Ford et al., J Neurophysiol 2008 : The effects of NGF on I ( Ca ) involve the mitogen activated protein kinase ( MAPK ) pathway
Yung et al., Cell Signal 2008 (MAP Kinase Signaling System) : Induction of p38 MAPK phosphorylation by NGF occurred in a time- and dose dependent manner and was partially inhibited by pertussis toxin ( PTX ) ... NGF dependent p38 MAPK phosphorylation became insensitive to PTX treatment upon transient expressions of Galpha ( z ) or the PTX-resistant mutants of Galpha ( i2 ) and Galpha ( oA ) ... NGF induced p38 MAPK phosphorylation was abolished by inhibitors of Src ( PP1, PP2, and SU6656 ) and MEK1/2 ( U0126 ) ... Collectively, these studies indicate that NGF dependent p38 MAPK activity may be mediated via G ( i2 ) protein, Src, and the MEK/ERK cascade
Mérot et al., Endocrinology 2009 : Importantly, 17betaE2 has no impact on NGF induced activity of MAPK and Akt signaling pathways
Tso et al., Neurochem Res 2009 : Nerve growth factor (NGF) mediated activation of mitogen activated protein kinases ( MAPK ) is critical for differentiation and apoptosis of PC12 cells
Chen et al., Neurosci Res 2009 (MAP Kinase Signaling System) : Conversely, NGF stimulation had no effect on FAK phosphorylation but led to a approximately 3.1 and approximately 2 fold increase in phosphorylation of MAPK and JNK
Julio-Pieper et al., J Clin Endocrinol Metab 2009 (MAP Kinase Signaling System) : NGF induces MAPK-ERK2 phosphorylation, and blockade of this signaling pathway prevents the NGF induced increase in VEGF production
Washio et al., Exp Cell Res 2009 : Western blot analysis revealed that HA suppressed NGF induced phosphorylation of p38 MAPK , ERKs, and transcriptional factor CREB in PC12 cells
Chung et al., J Biol Chem 2010 (Cystitis...) : These results indicate that endogenous NGF plays an important role in the activation of Akt and MAPK in the urinary bladder and in bladder hypertrophy during cystitis
Leugers et al., J Biol Chem 2010 (MAP Kinase Signaling System) : Tau potentiates nerve growth factor induced mitogen activated protein kinase signaling and neurite initiation without a requirement for microtubule binding ... The effect of Tau on AP-1 activation is mediated through its ability to potentiate the activation of mitogen activated protein kinase ( MAPK ), which occurs in response to both NGF and epidermal growth factor
Schmitz et al., Cell Mol Neurobiol 2011 : Our data showed that cavtratin suppresses the NGF induced phosphorylation of TrkA as well as the activation of MAPK in porcine oligodendrocytes significantly
Alsina et al., PloS one 2012 (MAP Kinase Signaling System) : In this work, we demonstrate that overexpression of wild-type Spry4 causes a significant reduction in MAPK and Rac1 activation and neurite outgrowth induced by NGF ... At molecular level, our findings indicate that ectopic expression of a mutated form of Spry4 ( Y53A ), in which a conserved tyrosine residue was replaced, fail to block both TrkA mediated Erk/MAPK activation and neurite outgrowth induced by NGF , suggesting that an intact tyrosine 53 site is required for the inhibitory effect of Spry4 on NGF signaling ... Downregulation of Spry4 using small interference RNA knockdown experiments potentiates PC12 cell differentiation and MAPK activation in response to NGF
Morillo et al., Mol Cell Biol 2012 (Nerve Degeneration) : We demonstrate that the activation of p75 ( NTR ) by nerve growth factor (NGF) induces nuclear p38 ( MAPK ) kinase activity, which leads to Thr phosphorylation and subsequent recruitment of E2F4 to the E2F-responsive cdc2 promoter
Al-Gayyar et al., PloS one 2013 (Diabetes Mellitus, Experimental...) : Inhibiting RhoA kinase with Y27632 significantly reduced diabetes- and proNGF induced activation of proapoptotic p38MAPK/JNK , expression of cleaved-PARP and caspase-3 and prevented retinal neurodegeneration in vivo and in vitro
Wuhanqimuge et al., FEBS open bio 2013 : Lysophosphatidylcholine enhances NGF induced MAPK and Akt signals through the extracellular domain of TrkA in PC12 cells ... Exogenously added secretory PLA2 ( sPLA2 ) enhanced NGF induced MAPK phosphorylation at a comparable level to LPC, suggesting that LPC generated in situ by sPLA2 mediated hydrolysis of membrane PC stimulated NGF-TrkA signal
Yao et al., J Biol Chem 1995 (Adrenal Gland Neoplasms...) : Both epidermal growth factor and nerve growth factor stimulate mitogen activated protein ( MAP ) kinase in these cells
Franklin et al., J Immunol 1995 : NGF induced shifts in p90rsk mobility displayed similar dose and time kinetics as NGF induced MAPK activation ... Activation of both MAPK and p90rsk occurred with doses of NGF as low as 400 pg/ml. Preincubation of NGF with anti-NGF Ab inhibited NGF induced activation of MAPK and p90rsk
Dikic et al., Curr Biol 1994 : Stimulation with nerve growth factor leads to the sustained activation and nuclear translocation of mitogen activated protein ( MAP ) kinase
Baxter et al., Eur J Biochem 1995 : However, the activation of p70S6K by PDGF ( or nerve growth factor ), but not the activation of mitogen-activated-protein kinase , was prevented by two structurally unrelated inhibitors of inositol phospholipid 3-kinase, wortmannin or LY294002
Hundle et al., J Biol Chem 1995 : In these cells, ethanol increases levels of delta-PKC and epsilon-PKC and markedly enhances nerve growth factor (NGF) induced neurite outgrowth and activation of mitogen activated protein ( MAP ) kinases by a PKC dependent mechanism
Decker et al., J Biol Chem 1995 : NGF caused a prolonged activation of mitogen activated protein kinase relative to EGF
Cohen et al., J Neurosci 1996 : NGF and NT-3 both induced the phosphorylation of mitogen activated protein kinase ( MAPK ) in OLPs and in OLs
Morishima-Kawashima et al., Mol Biol Cell 1996 : Although MAPK was activated by nerve growth factor in PC12 cells, the activity of microtubule associated MAPK did not further increase
Virdee et al., J Neurochem 1996 : To investigate whether these MAPK activities are necessary for NGF induced survival, we have inhibited NGF stimulated p42/p44 MAPK activity over extended periods using the compound 2- ( 2'-amino-3'-methoxyphenyl ) -oxanaphthalen-4-one ( PD98059 )
Kleijn et al., FEBS Lett 1996 : This excludes a role for MAPK in NGF- and EGF induced PHAS-I phosphorylation in PC12 cells
Arslan et al., Neuropharmacology 1997 : Stimulation of the cells with the non-selective adenosine receptor agonist N-ethylcarboxamidoadenosine ( NECA ) inhibited NGF induced mitogen activated protein kinase activation
Cardinaux et al., Brain Res Mol Brain Res 1997 : Phosphorylation of stathmin is specific for BDNF since nerve growth factor does not stimulate MAPK and stathmin phosphorylation in cultured cortical neurons
Nakamura et al., J Biol Chem 1998 : In neuronal cells such as PC12, Shc was demonstrated to be involved in vitro in Ras dependent mitogen activated protein kinase activation following nerve growth factor stimulation and Ca2+ entry
Yao et al., J Biol Chem 1998 : Induction of neuronal differentiation of the rat pheochromocytoma cell line, PC12 cells, by nerve growth factor (NGF) requires activation of the mitogen activated protein ( MAP ) kinase or extracellular signal regulated kinase ( ERK )
Xing et al., Mol Cell Biol 1998 : In addition to the ERK/RSK pathway, we found that NGF activated the p38 MAPK and its downstream effector, MAPK activated protein kinase 2 ( MAPKAP kinase 2 ), resulting in phosphorylation of CREB at Ser-133
Ikeuchi et al., J Biochem 1998 : MS-430 also prolonged the NGF induced phosphorylation of MAPK , but the phosphorylation of TrkA induced by NGF was not affected by MS-430
Burry et al., J Neurosci Res 1998 : Thus, PMA preincubation did not increase the length NGF activation of MAPK
Meakin et al., J Neurochem 1998 : Cells of the nnr5 line stably expressing TrkAS3 induce NGF dependent SHC phosphorylation and phosphatidylinositol 3-kinase, phospholipase Cgamma-1, and prolonged mitogen activated protein kinase activation to absolute levels comparable to those in PC12 cells
Qian et al., Neuron 1998 : Moreover, rAPS and SH2-B bind to Grb2, and both are sufficient to mediate NGF induction of Ras, MAP kinase ( MAPK ) , and morphological differentiation of PC12 cells
Powers et al., Cell Tissue Res 1999 : NGF induced phosphorylation of ras mediated mitogen activated protein kinases ( MAPK ) Erk1 and Erk2 is as prolonged in normal chromaffin cells as in PC12 cells, where NGF is neuritogenic