Gene interactions and pathways from curated databases and text-mining

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Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Mamet et al., J Biol Chem 2003 (Inflammation) : We previously showed that low endogenous NGF was responsible for ASIC3 basal expression and high NGF during inflammation increased ASIC3 expression parallely to the development of neuron hyperexcitability associated with hyperalgesia
Peters et al., J Histochem Cytochem 2006 : However, if proNGF is involved or if NGF can also promote hair growth via TrkA is unclear
Salehi et al., J Neural Transm 2004 (Alzheimer Disease...) : The delivery of sufficient amounts of NGF signal to BFCN cell bodies depends on the effective participation of several factors including sufficient synthesis and release of NGF , adequate synthesis and expression of NGF receptors by BFCNs, normal signaling and retrograde transport of NGF-receptor complex, and finally effective induction of gene expression by NGF
Ji et al., Regul Pept 1996 : Taken together, the present results suggest ( 1 ) that aFGF, bFGF and NGF differentially regulate neuropeptide expression in vivo ; ( 2 ) that FGFs can inhibit neuropeptide upregulation of some peptides after nerve injury ; and ( 3 ) that aFGF and NGF may induce pain related behavior
Montero et al., J Neurosci 1988 : These findings suggest that NGF prevents the lesion induced degeneration of cholinergic neurons by directly acting on NGF-R expressed by cholinergic cells and that NGF does not affect any neuron with an axonal lesion
Denkins et al., Neuro Oncol 2004 (Brain Neoplasms...) : Human melanoma cell lines express low-affinity NT receptor p75NTR in relation to their brain-metastatic propensity with their invasive properties being regulated by NGF , or nerve growth factor , the prototypic NT
Eibl et al., J Pharmacol Exp Ther 2010 : Y1036 binds BDNF ( K ( D ) = 3.5 +/- 0.3 microM ) and NGF ( K ( D ) = 3.0 +/- 0.4 microM ) preventing either BDNF or NGF from interacting with their obligate receptor ( s )
Safieh-Garabedian et al., Reproduction 2004 (Mastitis) : Nerve growth factor (NGF) levels increased in control and endotoxin treated cells in a time dependent manner, and endotoxin increased NGF levels in culture at 6 and 9 h post endotoxin treatment
Kirkland et al., Antioxid Redox Signal 2003 (MAP Kinase Signaling System) : It has been reported that NGF suppresses increased ROS production by the mitochondria in these cells through a mitogen activated protein kinase kinase ( MEK ) /mitogen activated protein ( MAP ) kinase pathway because NGF withdrawal inactivates this pathway and the MEK inhibitor, PD98059, increases ROS in the presence of NGF
Fahnestock et al., Biochemistry 1991 : These studies further supported the view that beta-NGF-endopeptidase acts on both NGF and kininogen
Colangelo et al., Brain Res Mol Brain Res 1996 (Glioma) : Correlation between increased AP-1NGF binding activity and induction of nerve growth factor transcription by multiple signal transduction pathways in C6-2B glioma cells
Castellon et al., J Neurosci Res 2000 (Brain Neoplasms...) : In conclusion, beta-NGF gene transfer into wild-type NET cells induces the synthesis and secretion of NGF , temporarily decreases cell proliferation rate, increases neurite extrusion, down-regulates NGF binding sites, and reduces NET cell responsiveness to NGF
Rockow et al., Oncogene 1996 (Adrenal Gland Neoplasms...) : We report here that the overexpressed Nck caused continued proliferation of PC12 cells even in the presence of NGF and blocked both the NGF- and bFGF induced neurite outgrowth
Negro et al., Neurochem Res 1993 : Affinity purified anti-NGF IgG consistently recognized NGF and NT-3 on Western blots, and inhibited the trophic activity of NGF and NT-3 but not BDNF
Webb et al., Alcohol Clin Exp Res 1996 : Our results indicated that behaviorally relevant levels of EtOH caused a rapid transient increase in basal [ Ca2+ ] i, whereas there was no effect of NGF on basal [ Ca2+ ] i. Ethanol and NGF interacted, resulting in the lowering of [ Ca2+ ] i
Charchar et al., Hypertension 1998 (Hypertension) : Nerve growth factor (NGF) determines sympathetic innervation of target tissues, and NGF levels are increased in young spontaneously hypertensive rats ( SHR )
Olson et al., Dev Neurosci 1979 : It is concluded that the developing locus coeruleus area does not contain or produce NGF , does not depend on NGF for fiber production, and is not stimulated by exogenous NGF
Barker et al., Neuron 1994 : By preventing NGF binding to p75LNTR, NGF binding to TrkA and NGF mediated signal transduction were reduced
Jamen et al., J Neurochem 2002 (MAP Kinase Signaling System) : NGF and IGF-1 increased endogenous PAC1 mRNA levels, and the NGF induced up-regulation is the result of an increase in transcription from PAC1 promoter instead of an increase in mRNA stability