Louhelainen et al., J Hypertens 2006
(Hypertension...) :
The detrimental effects of CsA were associated with upregulation of myocardial atrial natriuretic peptide (ANP) mRNA expression, paradoxical activation of the renin-angiotensin system (RAS) , induction of renal reduced nicotinamide-adenine dinucleotide phosphate ( NADPH ) oxidase , and overexpression of oxidative stress induced transcription factor NRF2
Grote et al., Cardiovasc Res 2006
(Cardiomegaly) :
Renin-angiotensin system (RAS) activation leads to increased production of NAD ( P ) H oxidase derived reactive oxygen species ( ROS ), and both have been implicated in the initiation and progression of arterial hypertension, atherosclerosis, and cardiac hypertrophy