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Activation of Rap1 was involved in the RET/PTC1 mediated stimulation of the BRAF kinase and the p42/p44 mitogen activated protein kinases
Guimond et al., Eur J Pharmacol 2013
:
As Ang II, C21/M024 induced a Rap1 dependent activation of p42/p44(mapk) whereas preincubation of cells with C38/M132 inhibited p42/p44(mapk) and Rap1 activation induced by Ang II