Gene interactions and pathways from curated databases and text-mining

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ODC1 — PIK3CA

Text-mined interactions from Literome

Facchini et al., FEBS Lett 2005 : In turn Src can activate PI3K and PKC-delta, and all these signaling proteins are required for ODC induction
Wei et al., Am J Physiol Cell Physiol 2008 : The data illustrated that PD-98059, a MEK ( MAPK kinase ) inhibitor, LY-294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor, and H-89, a protein kinase A (PKA) inhibitor, substantially decreased the induction of ODC catalytic activity and ODC mRNA expression induced by IL-4 and IL-13, suggesting positive regulation of the ODC gene by ERK, PI3K , and PKA pathways
Flamigni et al., Biochem Biophys Res Commun 1997 (Leukemia L1210) : These results indicate that PI3K activity is required for the induction of ODC , possibly affecting both ODC mRNA level and translation ... However, LY294002 and wortmannin at concentrations which inhibited almost completely PI3K activity did not decrease p70S6K activity, suggesting that p70S6K does not mediate the PI3K effects on ODC , but may lie on a separate pathway in this experimental model