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CASP4 — P2RX7

Text-mined interactions from Literome

Rothwell et al., Brain Behav Immun 2003 (Brain Injuries) : Release and cleavage of active IL-1 beta may be achieved via purinergic P2X7 receptors and activation of caspase-1
Kahlenberg et al., J Immunol 2005 : Stimulation of the P2X7 receptor (P2X7R) , an ATP gated ion channel, triggers rapid activation of caspase-1 ... In this study we demonstrate that pretreatment of primary and Bac1 murine macrophages with TLR agonists is required for caspase-1 activation by P2X7R but it is not required for activation of the receptor itself ... This priming by LPS is dependent on protein synthesis, given that cyclohexamide blocks the ability of LPS to prime macrophages for activation of caspase-1 by the P2X7R ... This protein synthesis is likely mediated by NF-kappaB, as pretreatment of cells with the proteasome inhibitor MG132, or the IkappaB kinase inhibitor Bay 11-7085 before LPS stimulation blocks the ability of LPS to potentiate the activation of caspase-1 by the P2X7R
Verhoef et al., J Immunol 2005 : Inhibitory effects of chloride on the activation of caspase-1 , IL-1beta secretion, and cytolysis by the P2X7 receptor
Raffaghello et al., Cancer Res 2006 (Neuroblastoma) : In contrast to the usual response typically observed in the majority of cell types, P2X(7) in vitro stimulation did not induce caspase-3 activation or apoptosis of neuroblastoma cells but rather supported their proliferation
Pelegrin et al., EMBO J 2006 : Here, we identify pannexin-1, a recently described mammalian protein that functions as a hemichannel when ectopically expressed, as this dye-uptake pathway and show that signalling through pannexin-1 is required for processing of caspase-1 and release of mature IL-1beta induced by P2X(7) receptor activation
Delarasse et al., J Neurochem 2009 (Necrosis) : Prolonged activation of P2X7R with these nucleotides leads to caspase independent death of NPCs. P2X7R ligation induces NPC lysis/necrosis demonstrated by cell membrane disruption accompanied with loss of mitochondrial membrane potential
Muñoz-Planillo et al., J Immunol 2009 (Inflammation...) : Notably, caspase-1 activation induced by S. aureus supernatant was independent of the P2X7 receptor and the essential TLR adaptors MyD88 and TIR domain containing adapter inducing IFN-beta, but was inhibited by extracellular K ( + )
Harder et al., J Immunol 2009 (Disease Models, Animal...) : Unlike activation of the Nlrp3 inflammasome by TLR ligands, the induction of caspase-1 activation by S. pyogenes did not require exogenous ATP or the P2X7R
Cesaro et al., Am J Physiol Gastrointest Liver Physiol 2010 (Inflammatory Bowel Diseases) : The aims of the present study were 1 ) to examine P2X(7)R expression in IEC ( T84 cells ) and in human intestinal biopsies ; 2 ) to detect any changes in P2X(7)R expression in T84 cells during PMNL transepithelial migration, and during the active and quiescent phases of IBD ; and 3 ) to test whether P2X(7)R stimulation in T84 monolayers can induce caspase-1 activation and IL-1beta release by IEC
Liao et al., J Leukoc Biol 2013 : Moreover, statin induced caspase-1 activation and IL-1ß production in LPS primed THP-1 cells are dependent on GGPP deficiency and P2X7 activation