Gene interactions and pathways from curated databases and text-mining

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CASP6 — PANX1

Text-mined interactions from Literome

Pelegrin et al., J Biol Chem 2007 : Inhibition of pannexin-1 blocked caspase-1 and IL-1beta processing and release in response to all three stimuli
Kanneganti et al., Immunity 2007 (Inflammation) : Instead, caspase-1 activation required pannexin-1 , a hemichannel protein that interacts with the P2X(7) receptor
Sandilos et al., J Biol Chem 2012 : Pannexin 1 (PANX1) channels mediate release of ATP, a `` find-me '' signal that recruits macrophages to apoptotic cells ; PANX1 activation during apoptosis requires caspase mediated cleavage of PANX1 at its C terminus, but how the C terminus inhibits basal channel activity is not understood