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PDCD10 — TP53

Text-mined interactions from Literome

Yin et al., Mol Carcinog 1999 (Carcinoma, Non-Small-Cell Lung...) : In this paper, we report that p53 was required for programmed cell death induced by oxidative stress in both mouse and human cells and that p53 transactivation was involved in induction of oxidative cell death
Frederick et al., Clin Cancer Res 1999 (Carcinoma, Squamous Cell...) : Expression of apoptosis related genes in human head and neck squamous cell carcinomas undergoing p53 mediated programmed cell death
Unger et al., Oncogene 1999 (Cell Transformation, Neoplastic) : The role of these mutations in regulating p53 mediated growth suppression and programmed cell death was examined
Yuan et al., Nature 1999 : The tyrosine kinase c-Abl is activated by certain DNA damaging agents and contributes to the induction of programmed cell death ( apoptosis ) by p53 dependent and p53 independent mechanisms
Horikoshi et al., Biochem Biophys Res Commun 1999 (Colonic Neoplasms) : Overexpression of p53 induces either growth arrest or programmed cell death ( apoptosis )
Sionov et al., Oncogene 1999 : p53 induces either growth arrest, which prevents the replication of damaged DNA, or programmed cell death ( apoptosis ), which is important for eliminating defective cells
Schuler et al., J Biol Chem 2000 : In contrast, N-acetylcysteine, even at high concentrations, could not prevent induction of programmed cell death by p53 expression
Juan et al., J Biol Chem 2000 : p53 , the most commonly mutated gene in cancer cells, directs cell cycle arrest or induces programmed cell death ( apoptosis ) in response to stress
Padovan et al., Eur J Gynaecol Oncol 2000 (Carcinoma, Squamous Cell...) : Since bcl-2 and p53 are implicated in the regulation of programmed cell death , very probably they play a role in carcinogenesis and consequently become prognostic factors
Kokontis et al., Oncogene 2001 (Carcinoma...) : The tumor suppressor p53 is an inducer of cell cycle arrest and programmed cell death ( apoptosis )
Nakagawara et al., Cancer Lett 2001 (Neoplasms) : Furthermore, developmentally programmed cell death of neuron, which is largely regulated by neurotrophin signaling, is at least in part controlled by tumor suppressors p53 and p73 as well as their antagonist DeltaNp73
Koty et al., Lung Cancer 2002 (Carcinoma, Non-Small-Cell Lung...) : In vivo expression of p53 and Bcl-2 and their role in programmed cell death in premalignant and malignant lung lesions
Li et al., Molecular vision 2002 : Developmental RGC programmed cell death does not require p53
Ricevuto et al., Tumori 2003 (Breast Neoplasms...) : P53 mutations are associated with worse prognosis and with chemo/radioresistance, due to the inability to trigger p53 dependent programmed cell death
Salomoni et al., Blood 2005 : PML is essential for p53 dependent induction of programmed cell death upon gamma-irradiation through PML-nuclear body ( NB ) -mediated control of p53 acetylation
Balogh et al., Int J Oncol 2006 (Breast Neoplasms...) : When damage to DNA is unrepairable, p53 induces programmed cell death ( apoptosis )
Pietsch et al., Oncogene 2006 (Disease Models, Animal...) : It is generally accepted that the ability of p53 to induce either growth arrest or programmed cell death in response to diverse stimuli underlies the powerful selection against this protein in the development of cancer
Crighton et al., Autophagy 2007 : DRAM is a lysosomal protein that is not only critical for the ability of p53 to induce autophagy, but also for p53 's ability to induce programmed cell death -- a facet of p53 considered central to its tumor-suppressive effects
Facoetti et al., Anticancer Res 2008 (Astrocytoma...) : Proliferation and programmed cell death : role of p53 protein in high and low grade astrocytoma
Pietsch et al., Oncogene 2008 : The ability of p53 to induce programmed cell death , or apoptosis, of cells exposed to environmental or oncogenic stress constitutes a major pathway whereby p53 exerts its tumor suppressor function
Liu et al., Cancer Res 2009 (Neoplasms) : Proline oxidase (POX), catalyzing the first step in proline catabolism, is induced by p53 and can regulate cell survival as well as mediate programmed cell death
Liu et al., Molecular cancer 2011 (Melanoma...) : MI-319 alone increased p53 levels and p53 dependent gene expression in melanoma cells but did not induce programmed cell death
Lin et al., Mol Cell Biol 1995 (Cell Transformation, Neoplastic) : The adenovirus E1A oncogene products stimulate DNA synthesis and cell proliferation but fail to transform primary baby rat kidney ( BRK ) cells because of the induction of p53 mediated programmed cell death ( apoptosis )
Eizenberg et al., EMBO J 1995 : Direct involvement of p53 in programmed cell death of oligodendrocytes
Caelles et al., Nature 1994 : The tumour suppressor p53 is required to induce programmed cell death ( apoptosis ) by DNA damaging agents
Eizenberg et al., Mol Cell Biol 1996 : This study demonstrated the involvement of the tumor suppressor protein p53 in differentiation and programmed cell death of neurons and oligodendrocytes, two cell types that leave the mitotic cycle early in development and undergo massive-scale cell death as the nervous system matures
Ghosh-Choudhury et al., Biochem Biophys Res Commun 1997 : These cell lines offer a model system to study the role of p53 in osteoblastic differentiation and programmed cell death
Theis et al., Int J Cancer 1997 : p53 mediated programmed cell death ( PMCD ) often requires an intact transactivation domain of the p53 tumor suppressor and is therefore usually interpreted to rely upon the transactivation of genes
Haupt et al., Leukemia 1997 (Cell Transformation, Neoplastic) : The anti-proliferative activity of p53 can be mediated by the induction of growth arrest and/or programmed cell death ( apoptosis )
Chirillo et al., Proc Natl Acad Sci U S A 1997 : The hepatitis B virus X gene induces p53 mediated programmed cell death
Gomez-Manzano et al., J Natl Cancer Inst 1997 (Brain Neoplasms...) : In addition, our results document that p21 plays a role in protecting cells from p53 mediated programmed cell death and suggest that p53 mediated apoptosis and p21 induction may represent, at least in certain cases, opposite signals
Polyak et al., Nature 1997 : Expression of p53 induces either a stable growth arrest or programmed cell death ( apoptosis )
Parsels et al., Mol Pharmacol 1997 (Colonic Neoplasms) : Temporary expression of wild-type p53 activity in the absence of drug treatment caused some loss of clonogenicity, although the magnitude of this cytotoxic effect was small compared with the level of cell kill obtained by treatment with cytotoxic drugs for similar periods of time, indicating that HT29 cells are not highly sensitive to induction of programmed cell death by wild-type p53
Cox et al., J Pathol 1997 (Cell Transformation, Neoplastic) : Current research highlights the action of a p53 activated gene, p21Cip1/WAF1/Sdi1, which encodes a cyclin-kinase inhibitor important in mediating p53 dependent cell-cycle arrest, while programmed cell death in response to DNA damage requires transcriptionally active p53 but not activation of p21Cip1/WAF1/Sdi1
Moll et al., Crit Rev Oral Biol Med 1998 (Cell Transformation, Neoplastic...) : When cells are subject to ionizing radiation or other mutagenic events, p53 mediates cell cycle arrest or programmed cell death ( apoptosis )
Li et al., Breast Cancer Res Treat 1998 (Breast Neoplasms) : The results demonstrate that persistent, high level expression of recombinant p53 can induce programmed cell death in MCF-7 cells
Meek et al., Pathol Biol (Paris) 1997 : Activation of p53 leads either to cellular growth arrest at the G1/S or G2/M transitions of the cell cycle or to programmed cell death ( apoptosis )